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The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance
Further development in organ transplantation requires the utilization of new immunosuppressive drugs that-in addition to being effective against rejection-do not block tolerance. We previously reported that FTY 720, a drug that alters lymphocyte trafficking, has marked anti-rejection properties. We...
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| Published in: | Transplant international 2003-06, Vol.16 (6), p.383-390 |
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| container_end_page | 390 |
| container_issue | 6 |
| container_start_page | 383 |
| container_title | Transplant international |
| container_volume | 16 |
| creator | KOSHIBA, Takaaki VAN DAMME, Boudewijn PING JI SEFRIOUI, Hassan RUTGEERTS, Omer WAER, Mark PIRENNE, Jacques |
| description | Further development in organ transplantation requires the utilization of new immunosuppressive drugs that-in addition to being effective against rejection-do not block tolerance. We previously reported that FTY 720, a drug that alters lymphocyte trafficking, has marked anti-rejection properties. We now investigate how FTY 720 influences tolerance in a model of graft acceptance by donor-specific blood transfusion (DSBT). Two different transplant models--heart transplantation (Htx) and intestinal transplantation (Itx)--were studied. We performed orthotopic Itx and heterotopic Htx using fully mismatched inbred male RA (RT1(p)) and PVG (RT1(c)) rats as donors and recipients. Tolerance was induced by DSBT on pre-transplant day -12. To test the effect of FTY 720 on DSBT-induced tolerance, we administered FTY 720 orally prior to DSBT. Itx: control rats succumbed to rejection at 18+/-4 days. DSBT alone prolonged survival to 101.9+/-18 days (P |
| doi_str_mv | 10.1007/s00147-002-0523-9 |
| format | article |
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We previously reported that FTY 720, a drug that alters lymphocyte trafficking, has marked anti-rejection properties. We now investigate how FTY 720 influences tolerance in a model of graft acceptance by donor-specific blood transfusion (DSBT). Two different transplant models--heart transplantation (Htx) and intestinal transplantation (Itx)--were studied. We performed orthotopic Itx and heterotopic Htx using fully mismatched inbred male RA (RT1(p)) and PVG (RT1(c)) rats as donors and recipients. Tolerance was induced by DSBT on pre-transplant day -12. To test the effect of FTY 720 on DSBT-induced tolerance, we administered FTY 720 orally prior to DSBT. Itx: control rats succumbed to rejection at 18+/-4 days. DSBT alone prolonged survival to 101.9+/-18 days (P<0.05 vs untreated). Long-term survivors were tolerant (acceptance of secondary donor-specific Htx). Adjunction of FTY 720 prior to DSBT reduced survival to 55.9+/-44.7 days (P<0.05). However, long-term survivors still accepted secondary donor-specific Htx. Htx: control rats survived 9+/-0.6 days. DSBT alone prolonged survival indefinitely (>120 days) and induced tolerance (acceptance of secondary donor-specific Htx). Unlike in Itx, adjunction of FTY 720 prior to DSBT did not reduce Htx survival. Acceptance of secondary donor-specific Htx was not influenced by FTY 720. In Itx, FTY 720 counteracts the beneficial effect of pre-transplant DSBT and triggers acute rejection of primary, but not secondary grafts. In Htx, however, FTY 720 allows full development of tolerance. The mechanisms by which FTY 720 causes rejection in primary intestinal but not in heart grafts need to be elucidated.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1007/s00147-002-0523-9</identifier><identifier>PMID: 12819868</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing</publisher><subject>Animals ; Antibodies, Anti-Idiotypic - immunology ; Antibody Formation ; Biological and medical sciences ; Blood Transfusion ; Fingolimod Hydrochloride ; Heart Transplantation ; Histocompatibility ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Immunomodulators ; Immunosuppressive Agents - pharmacology ; Intestines - transplantation ; Lymphocyte Culture Test, Mixed ; Lymphocyte Subsets - drug effects ; Lymphocytes - drug effects ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Propylene Glycols - pharmacology ; Rats ; Rats, Inbred Strains ; Sphingosine - analogs & derivatives ; Tissue Donors ; Transplantation Conditioning - methods ; Transplantation Tolerance ; Transplantation, Heterotopic ; Transplantation, Homologous</subject><ispartof>Transplant international, 2003-06, Vol.16 (6), p.383-390</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14924149$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12819868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOSHIBA, Takaaki</creatorcontrib><creatorcontrib>VAN DAMME, Boudewijn</creatorcontrib><creatorcontrib>PING JI</creatorcontrib><creatorcontrib>SEFRIOUI, Hassan</creatorcontrib><creatorcontrib>RUTGEERTS, Omer</creatorcontrib><creatorcontrib>WAER, Mark</creatorcontrib><creatorcontrib>PIRENNE, Jacques</creatorcontrib><title>The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Further development in organ transplantation requires the utilization of new immunosuppressive drugs that-in addition to being effective against rejection-do not block tolerance. We previously reported that FTY 720, a drug that alters lymphocyte trafficking, has marked anti-rejection properties. We now investigate how FTY 720 influences tolerance in a model of graft acceptance by donor-specific blood transfusion (DSBT). Two different transplant models--heart transplantation (Htx) and intestinal transplantation (Itx)--were studied. We performed orthotopic Itx and heterotopic Htx using fully mismatched inbred male RA (RT1(p)) and PVG (RT1(c)) rats as donors and recipients. Tolerance was induced by DSBT on pre-transplant day -12. To test the effect of FTY 720 on DSBT-induced tolerance, we administered FTY 720 orally prior to DSBT. Itx: control rats succumbed to rejection at 18+/-4 days. DSBT alone prolonged survival to 101.9+/-18 days (P<0.05 vs untreated). Long-term survivors were tolerant (acceptance of secondary donor-specific Htx). Adjunction of FTY 720 prior to DSBT reduced survival to 55.9+/-44.7 days (P<0.05). However, long-term survivors still accepted secondary donor-specific Htx. Htx: control rats survived 9+/-0.6 days. DSBT alone prolonged survival indefinitely (>120 days) and induced tolerance (acceptance of secondary donor-specific Htx). Unlike in Itx, adjunction of FTY 720 prior to DSBT did not reduce Htx survival. Acceptance of secondary donor-specific Htx was not influenced by FTY 720. In Itx, FTY 720 counteracts the beneficial effect of pre-transplant DSBT and triggers acute rejection of primary, but not secondary grafts. In Htx, however, FTY 720 allows full development of tolerance. The mechanisms by which FTY 720 causes rejection in primary intestinal but not in heart grafts need to be elucidated.</description><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Fingolimod Hydrochloride</subject><subject>Heart Transplantation</subject><subject>Histocompatibility</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Intestines - transplantation</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Lymphocyte Subsets - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Propylene Glycols - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Tissue Donors</subject><subject>Transplantation Conditioning - methods</subject><subject>Transplantation Tolerance</subject><subject>Transplantation, Heterotopic</subject><subject>Transplantation, Homologous</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdkMFqGzEQhkVpqB2nD9BLEIHktulopF1pj8HUSSHQQ51DTkKrHbU2uytntT707SPHBkMvEkjf_PPzMfZNwL0A0N8TgFC6AMACSpRF_YnNhZJYIGr9mc2hlqoAo9WMXaa0hQyaEr6wmUAjalOZOfu9_kucQiA_8Rj4av3KNQKPA6fhz-jC1NMw8c3AHe9jS90BSrs4TG6guE_cdV384Ljznnb52dMVuwiuS_T1dC_Yy-rHevlUPP96_Ll8eC68hGrKJaumIZRCKiCjZUkVYiAQUGndOoUOa9OGqsFKkUEZGuPbVlYY8qcGlAt2d8zdjfFtT2my_SZ56rpjN6tzcFmWJoM3_4HbuB-H3M2iqEtd5w0ZEkfIjzGlkYLdjZvejf-sAHvQbY-6bbZoD7ptnWeuT8H7pqf2PHHym4HbE-CSd10Ys59NOnOqRpUP-Q54t4U-</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>KOSHIBA, Takaaki</creator><creator>VAN DAMME, Boudewijn</creator><creator>PING JI</creator><creator>SEFRIOUI, Hassan</creator><creator>RUTGEERTS, Omer</creator><creator>WAER, Mark</creator><creator>PIRENNE, Jacques</creator><general>Blackwell Publishing</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030601</creationdate><title>The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance</title><author>KOSHIBA, Takaaki ; VAN DAMME, Boudewijn ; PING JI ; SEFRIOUI, Hassan ; RUTGEERTS, Omer ; WAER, Mark ; PIRENNE, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-226bbe231340e8735e622fe010677da42a298df6b264e823fb8cdd362fda47023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - immunology</topic><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>Fingolimod Hydrochloride</topic><topic>Heart Transplantation</topic><topic>Histocompatibility</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Intestines - transplantation</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Lymphocyte Subsets - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Propylene Glycols - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Tissue Donors</topic><topic>Transplantation Conditioning - methods</topic><topic>Transplantation Tolerance</topic><topic>Transplantation, Heterotopic</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOSHIBA, Takaaki</creatorcontrib><creatorcontrib>VAN DAMME, Boudewijn</creatorcontrib><creatorcontrib>PING JI</creatorcontrib><creatorcontrib>SEFRIOUI, Hassan</creatorcontrib><creatorcontrib>RUTGEERTS, Omer</creatorcontrib><creatorcontrib>WAER, Mark</creatorcontrib><creatorcontrib>PIRENNE, Jacques</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOSHIBA, Takaaki</au><au>VAN DAMME, Boudewijn</au><au>PING JI</au><au>SEFRIOUI, Hassan</au><au>RUTGEERTS, Omer</au><au>WAER, Mark</au><au>PIRENNE, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>16</volume><issue>6</issue><spage>383</spage><epage>390</epage><pages>383-390</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Further development in organ transplantation requires the utilization of new immunosuppressive drugs that-in addition to being effective against rejection-do not block tolerance. We previously reported that FTY 720, a drug that alters lymphocyte trafficking, has marked anti-rejection properties. We now investigate how FTY 720 influences tolerance in a model of graft acceptance by donor-specific blood transfusion (DSBT). Two different transplant models--heart transplantation (Htx) and intestinal transplantation (Itx)--were studied. We performed orthotopic Itx and heterotopic Htx using fully mismatched inbred male RA (RT1(p)) and PVG (RT1(c)) rats as donors and recipients. Tolerance was induced by DSBT on pre-transplant day -12. To test the effect of FTY 720 on DSBT-induced tolerance, we administered FTY 720 orally prior to DSBT. Itx: control rats succumbed to rejection at 18+/-4 days. DSBT alone prolonged survival to 101.9+/-18 days (P<0.05 vs untreated). Long-term survivors were tolerant (acceptance of secondary donor-specific Htx). Adjunction of FTY 720 prior to DSBT reduced survival to 55.9+/-44.7 days (P<0.05). However, long-term survivors still accepted secondary donor-specific Htx. Htx: control rats survived 9+/-0.6 days. DSBT alone prolonged survival indefinitely (>120 days) and induced tolerance (acceptance of secondary donor-specific Htx). Unlike in Itx, adjunction of FTY 720 prior to DSBT did not reduce Htx survival. Acceptance of secondary donor-specific Htx was not influenced by FTY 720. In Itx, FTY 720 counteracts the beneficial effect of pre-transplant DSBT and triggers acute rejection of primary, but not secondary grafts. In Htx, however, FTY 720 allows full development of tolerance. The mechanisms by which FTY 720 causes rejection in primary intestinal but not in heart grafts need to be elucidated.</abstract><cop>Oxford</cop><pub>Blackwell Publishing</pub><pmid>12819868</pmid><doi>10.1007/s00147-002-0523-9</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2003-06, Vol.16 (6), p.383-390 |
| issn | 0934-0874 1432-2277 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Animals Antibodies, Anti-Idiotypic - immunology Antibody Formation Biological and medical sciences Blood Transfusion Fingolimod Hydrochloride Heart Transplantation Histocompatibility Immunoglobulin G - immunology Immunoglobulin M - immunology Immunomodulators Immunosuppressive Agents - pharmacology Intestines - transplantation Lymphocyte Culture Test, Mixed Lymphocyte Subsets - drug effects Lymphocytes - drug effects Male Medical sciences Pharmacology. Drug treatments Propylene Glycols - pharmacology Rats Rats, Inbred Strains Sphingosine - analogs & derivatives Tissue Donors Transplantation Conditioning - methods Transplantation Tolerance Transplantation, Heterotopic Transplantation, Homologous |
| title | The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance |
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