Indications for 24-hour gastric pH monitoring with single and multiple probes in clinical research and practice

The methodology of prolonged gastric pH monitoring has not yet been standardized with regard to the number and position of pH probes. Twenty-seven healthy volunteers and 11 patients affected by nonulcer dyspepsia have been submitted to 24-hr ambulatory simultaneous pH monitoring of the distal esopha...

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Bibliographic Details
Published in:Digestive diseases and sciences 1992-12, Vol.37 (12), p.1793-1801
Main Authors: MATTIOLI, S, FELICE, V, PILOTTI, V, BACCHI, M. L, PASTINA, M, GOZZETTI, G
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Duodenogastric Reflux - metabolism
Dyspepsia - metabolism
Eating
Female
Gastric Acidity Determination
Gastric Fundus - metabolism
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Middle Aged
Monitoring, Physiologic - methods
Other diseases. Semiology
Pyloric Antrum - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:The methodology of prolonged gastric pH monitoring has not yet been standardized with regard to the number and position of pH probes. Twenty-seven healthy volunteers and 11 patients affected by nonulcer dyspepsia have been submitted to 24-hr ambulatory simultaneous pH monitoring of the distal esophagus, fundus, and antrum. Fundic and antral pH profiles have been compared and causes of pH variations (pH > 4) identified. Both in healthy volunteers and dyspeptic patients, percentile curves of fundic and antral pH were statistically different in more than one of the daily periods considered (24-hr, postprandial, interdigestive, nocturnal). Percent time of duodenogastric reflux is significantly higher in the antrum than in the fundus in both groups. Modalities of gastric alkalinization secondary to food or duodenogastric reflux were different for the fundus and for the antrum both in healthy and dyspeptic subjects and between the two groups. These differences suggest that single and multiple pH monitoring of the stomach have different indications, and the position of the probes should vary according to the purpose of the test.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01308070