Androstenediol reverses steroid-inhibited wound healing

• Published in: Wound repair and regeneration 2009-09, Vol.17 (5), p.758-761
• Main Authors: Feeser, V. Ramana, Menke, Nathan B., Ward, Kevin R., Loria, Roger M., Diegelmann, Robert F.
• Format: Article
• Language: English
• Subjects: Anabolic Agents - pharmacology; Androstenediol - pharmacology; Animals; Disease Models, Animal; Glucocorticoids - pharmacology; Male; Methylprednisolone - pharmacology; Mice; Skin - drug effects; Skin - injuries; Wound Healing - drug effects; Wound Healing - immunology; Wounds and Injuries - drug therapy; Wounds and Injuries - immunology
• ISSN: 1067-1927; 1524-475X
• DOI: 10.1111/j.1524-475X.2009.00528.x

ABSTRACT It is well recognized that stress of any nature will cause a delay in the wound healing response. This delayed healing response appears closely associated with immune regulators. In this study, CD‐1 mice were injected with a long acting form of methyl prednisolone to cause a steroid‐induced immune suppression. After 24 hours, two 6‐mm full thickness wounds were placed on the animals' backs and one group of animals received the immune‐regulating hormone, androstenediol. Wound contraction was quantified by planimetry for the subsequent 14 days. Animals that were stressed with methyl prednisolone but receiving androstenediol contracted their open wounds at faster rates compared with methyl prednisolone‐stressed animals treated with the vehicle alone. These findings suggest that restoration of immune regulation by androstenediol can reverse the delayed open wound contraction secondary to steroid stress.