In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB12402

In this paper, we characterize the novel human leucocyte antigen (HLA)‐DPB1*2402 allele that we found in a patient suffering from acne vulgaris. In comparison to the closest related allele DPB1*0401, HLA‐DPB1*2402 has a single nucleotide exchange at position 115 (202), T replaces G. In consequence,...

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Bibliographic Details
Published in:Tissue antigens 2009-10, Vol.74 (4), p.354-356
Main Authors: Witter, K., Kirchner, E., Borelli, C., Messer, G., Albert, T., Zahn, R., Kauke, T.
Format: Article
Language:English
Subjects:
acne
Acne Vulgaris - blood
Acne Vulgaris - genetics
allele separation
Alleles
Base Sequence
Histocompatibility Testing
HLA-DP Antigens - blood
HLA-DP Antigens - genetics
HLA-DP beta-Chains
human leukocyte antigen-DPB12402
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
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Summary:In this paper, we characterize the novel human leucocyte antigen (HLA)‐DPB1*2402 allele that we found in a patient suffering from acne vulgaris. In comparison to the closest related allele DPB1*0401, HLA‐DPB1*2402 has a single nucleotide exchange at position 115 (202), T replaces G. In consequence, codon 39 (68) TAC encodes for tyrosine in the novel allele instead of aspartic acid 39 (68) GAC in DPB1*0401. In November 2008, the DNA samples of a cohort of patients who were afflicted with acne vulgaris were sent to our laboratory for human leucocyte antigen (HLA) high‐resolution typing. This happens in course of a study of HLA pattern in respect to the disease. In one of these samples, a male patient of German Caucasoid origin (laboratory code 191849), we showed a novel DPB1 allele.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2009.01325.x