Formulation of multifunctional oil-in-water nanosized emulsions for active and passive targeting of drugs to otherwise inaccessible internal organs of the human body

Oil-in-water (o/w) type nanosized emulsions (NE) have been widely investigated as vehicles/carrier for the formulation and delivery of drugs with a broad range of applications. A comprehensive summary is presented on how to formulate the multifunctional o/w NE for active and passive targeting of dru...

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Bibliographic Details
Published in:International journal of pharmaceutics 2009-10, Vol.381 (1), p.62-76
Main Author: Tamilvanan, Shunmugaperumal
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Drug Compounding - methods
Drug Delivery Systems - methods
Emulsions - chemistry
Emulsions - therapeutic use
General pharmacology
Generations of emulsion
Genetic Therapy - methods
Humans
Medical sciences
Multifunctional
Nanosized emulsion
Nanostructures - chemistry
Nanostructures - therapeutic use
Opsonin Proteins - therapeutic use
Opsonization
Organ Specificity
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pharmacopoeial and safety issues
Unique property
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Summary:Oil-in-water (o/w) type nanosized emulsions (NE) have been widely investigated as vehicles/carrier for the formulation and delivery of drugs with a broad range of applications. A comprehensive summary is presented on how to formulate the multifunctional o/w NE for active and passive targeting of drugs to otherwise inaccessible internal organs of the human body. The NE is classified into three generations based on its development over the last couple of decades to make ultimately a better colloidal carrier for a target site within the internal and external organs/parts of the body, thus allowing site-specific drug delivery and/or enhanced drug absorption. The third generation NE has tremendous application for drug absorption enhancement and for ‘ferrying’ compounds across cell membranes in comparison to its first and second generation counterparts. Furthermore, the third generation NE provides an interesting opportunity for use as drug delivery vehicles for numerous therapeutics that can range in size from small molecules to macromolecules.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2009.08.001