Resolution of late sirolimus-eluting stent thrombosis after tirofiban treatment

A 40-year-old male patient was admitted to the hospital with acute chest pain. A sirolimus-eluting stent (SES) had been deployed to the circumflex artery (Cx) 3 years before. Now, inferior ST-segment elevations were observed and coronary angiography revealed stent thrombosis with distal TIMI 3 grade...

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Bibliographic Details
Published in:Heart and vessels 2009-09, Vol.24 (5), p.388-390
Main Authors: Karakurt, Ozlem, Cagirci, Goksel, Kilic, Harun, Akdemir, Ramazan
Format: Article
Language:English
Subjects:
Adult
Angioplasty, Balloon, Coronary - adverse effects
Angioplasty, Balloon, Coronary - instrumentation
Biomedical Engineering and Bioengineering
Blood clots
Cardiac Surgery
Cardiology
Cardiovascular Agents - administration & dosage
Case Report
Case studies
Coronary Angiography
Coronary Circulation
Coronary Thrombosis - diagnostic imaging
Coronary Thrombosis - drug therapy
Coronary Thrombosis - etiology
Coronary Thrombosis - physiopathology
Drug-Eluting Stents
Electrocardiography
Fibrinolytic Agents - administration & dosage
Humans
Infusions, Intra-Arterial
Male
Medicine
Medicine & Public Health
Pharmacology
Sirolimus - administration & dosage
Stents
Thrombolytic Therapy
Treatment Outcome
Tyrosine - administration & dosage
Tyrosine - analogs & derivatives
Vascular Surgery
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Description
Summary:A 40-year-old male patient was admitted to the hospital with acute chest pain. A sirolimus-eluting stent (SES) had been deployed to the circumflex artery (Cx) 3 years before. Now, inferior ST-segment elevations were observed and coronary angiography revealed stent thrombosis with distal TIMI 3 grade flow in the Cx. Tirofiban infusion was administered and the control angiography 2 days later revealed complete resolution of the thrombus. Stent thrombosis is a rare but usually poor prognostic event, frequently associated with large myocardial infarction (MI) or death. Very late drug-eluting stent (DES) thrombosis remains a major problem of interventional cardiology due to its high morbidity and mortality. We conclude that tirofiban may be an interesting candidate drug for treatment of very late stent thrombosis.
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-009-1149-y