Analysis of the oviductal glycoprotein 1 polymorphisms and their effects on components of litter size in rabbits

The objective of this work was to study the effect of the oviductal glycoprotein 1 (OVGP1) genotype and mRNA expression on litter size and other fertility measures, as OVGP1 has positive effects on fertilization and early embryo development. We have analysed an F₂ cross of two lines of rabbits diver...

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Bibliographic Details
Published in:Animal genetics 2009-10, Vol.40 (5), p.756-758
Main Authors: Merchán, M, Peiró, R, Argente, M.J, Santacreu, M.A, García, M.L, Blasco, A, Folch, J.M
Format: Article
Language:English
Subjects:
Animals
Base Sequence
candidate gene
Crosses, Genetic
Fallopian Tubes - chemistry
Female
Glycoproteins - genetics
Glycoproteins - metabolism
Haplotypes - genetics
litter size
Litter Size - genetics
Molecular Sequence Data
oviductal glycoprotein 1 gene
Polymorphism, Single Nucleotide - genetics
Promoter Regions, Genetic - genetics
rabbit
rabbits
Rabbits - genetics
Sequence Analysis, DNA - veterinary
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Summary:The objective of this work was to study the effect of the oviductal glycoprotein 1 (OVGP1) genotype and mRNA expression on litter size and other fertility measures, as OVGP1 has positive effects on fertilization and early embryo development. We have analysed an F₂ cross of two lines of rabbits divergently selected for uterine capacity. The OVGP1 mRNA expression was analysed in both lines, but no differences were observed between them. The promoter region and mRNA were sequenced in the F₀ generation, and 17 polymorphic sites were found to co-segregate in three haplotypes (A, B and C). An association study was performed between several reproductive traits and a triallelic microsatellite identified in the promoter region as well as a non-synonymous SNP located in exon 11 [g.12944C>G (p.Arg468Gly)]. The alleles g.12944G and g.325(GT)₁₄T(G)₅ of the B haplotype have a positive effect on the total number of kits born, number born alive, number of implanted embryos and foetal and prenatal embryo survival.
ISSN:0268-9146
1365-2052
DOI:10.1111/j.1365-2052.2009.01898.x