Comparative therapeutic effect of moxidectin, doramectin and ivermectin on psoroptes mites infestation in buffalo (Bubalus bubalis)

• Published in: Tropical animal health and production 2009-10, Vol.41 (7), p.1505-1511
• Main Authors: El-Khodery, Sabry A, Ishii, Mitsu, Osman, Salama A, Al-Gaabary, Magdy H
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Animals; Antiparasitic Agents - pharmacology; Antiparasitic Agents - therapeutic use; Biomedical and Life Sciences; Bubalus bubalis; Buffaloes; Deltamethrin; Egypt; Ivermectin - analogs & derivatives; Ivermectin - pharmacology; Ivermectin - therapeutic use; Life Sciences; Macrolides - pharmacology; Macrolides - therapeutic use; Mite Infestations - drug therapy; Mite Infestations - veterinary; Mites; Nitriles; Original Paper; Psoroptes; Psoroptidae - drug effects; Pyrethrins; Veterinary Medicine/Veterinary Science; Zoology
• ISSN: 0049-4747; 1573-7438
• DOI: 10.1007/s11250-009-9340-9

The aim of the present study was to carry out comparative therapeutic effect of moxidectin pour on, doramectin and ivermectin on psoroptes infestation in buffalo. A total of 318 buffalo in 77 small scale herds suspected to have mange mites were examined clinically and parasitologically. Fifty-three (16.66%) buffalo in 25 herds were recorded to be infested; 51 (16.35%) with psoroptic mites, and two (0.31%) with chorioptic mites. Buffalo with psoroptic mites were randomly allocated into three groups (17 buffalo each). First group was treated with moxidectin pour on at a dose rate of 0.5 mg kg⁻¹. The second group received doramectin (200 µg kg⁻¹ twice subcutaneously, 14 days apart). The third group received ivermectin (200 µg kg⁻¹ twice subcutaneously, 14 days apart). Adjunct to each drug, deltamethrin was applied to the surrounding environment twice at a two week interval. Treatment outcomes of 51 buffalo with psoroptic mites showed that moxidectin pour on and doramectin had a significant higher effect on mite count reduction (MANOVA, P