Correlation between HIV-1 seropositivity and prevalence of a γ-secretase polymorphism in two distinct ethnic populations

• Published in: Journal of medical virology 2009-11, Vol.81 (11), p.1847-1851
• Main Authors: van Loo, Karen M.J., van Schijndel, Jessica E., van Zweeden, Martine, van Manen, Daniëlle, Trip, Mieke D., Petersen, Desiree C., Schuitemaker, Hanneke, Hayes, Vanessa M., Martens, Gerard J.M.
• Format: Article
• Language: English
• Subjects: AIDS; Amino Acid Substitution - genetics; Amyloid Precursor Protein Secretases - genetics; APH1B polymorphism; Biological and medical sciences; Disease Susceptibility; Epidemiology; Female; Fundamental and applied biological sciences. Psychology; HIV Infections - genetics; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Membrane Proteins - genetics; Microbiology; Miscellaneous; Mutation, Missense; Peptide Hydrolases - genetics; Polymorphism, Single Nucleotide; susceptibility gene; Viral diseases; Virology
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.21601

Susceptibility for human immunodeficiency virus type 1 (HIV‐1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the γ‐secretase pathway may be associated with an individual's susceptibility to infection. A functional single‐nucleotide polymorphism (SNP) in the γ‐secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV‐1 infection. The SNP showed a tendency for association with HIV‐1 infection in a Xhosa indigenous South African Bantu study (P = 0.087), and associated significantly in a Caucasian Dutch study (P = 0.049). Together, the results suggest a role for the γ‐secretase pathway in susceptibility to HIV‐1 infection. J. Med. Virol. 81:1847–1851, 2009. © 2009 Wiley‐Liss, Inc.