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High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensives
Previous studies have linked essential sustained hypertension with Chlamydia pneumoniae ( C. pneumoniae) and changes in intima-media thickness (IMT) of carotid arteries. The aim of this study was to examine if similar associations exist in subjects with white-coat hypertension. C. pneumoniae IgA and...
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| Published in: | Atherosclerosis 2003-04, Vol.167 (2), p.231-235 |
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| container_end_page | 235 |
| container_issue | 2 |
| container_start_page | 231 |
| container_title | Atherosclerosis |
| container_volume | 167 |
| creator | Pitiriga, Vassiliki C. Kotsis, Vasilios T. Papamichail, Christos M. Alexandrou, Maria-Eleni K. Lekakis, John P. Kokolakis, Nikos Petrocheilou-Paschou, Vassiliky D. Zakopoulos, Nikos A. |
| description | Previous studies have linked essential sustained hypertension with
Chlamydia pneumoniae (
C. pneumoniae) and changes in intima-media thickness (IMT) of carotid arteries. The aim of this study was to examine if similar associations exist in subjects with white-coat hypertension.
C. pneumoniae IgA and IgG antibody titers were measured in 125 patients with white-coat hypertension and 54 normotensives. All participants underwent a 24 h ambulatory blood pressure (BP) monitoring, clinic BP readings and common-internal carotid artery IMT measurements. Seventy subjects of the white-coat group (56%) and 15 of the control group (27.8%) had IgG titers ≥80 (crosstabs;
P |
| doi_str_mv | 10.1016/S0021-9150(02)00426-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73406333</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915002004264</els_id><sourcerecordid>73406333</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-64934d79cae8829c65d232e60fefc591aca6a70330ae66f8a8cdf096f1564b933</originalsourceid><addsrcrecordid>eNqF0E1vEzEQgGELgdq09CdQ7QVUDgvjj_XapwpFQJEqONCerYl33Ljar9qboPx7Nk1Ej5zm8ow9ehl7x-ETB64__wYQvLS8gisQHwGU0KV6xRbc1LbkyqjXbPGPnLKznB9hVjU3J-yUC8ONgmrBft7Eh3UxJtpiS72nYgjFct1it2siFmNPm27oI1KB_RRXQxMpF7Ev_qzjRKUfcCrWu5HSRH2OW8pv2ZuAbaaL4zxn99--3i1vyttf338sv9yWXlo-lVpZqZraeiRjhPW6aoQUpCFQ8JXl6FFjDVICktbBoPFNAKsDr7RaWSnP2YfDu2ManjaUJ9fF7Kltsadhk10tFWgp97A6QJ-GnBMFN6bYYdo5Dm4f0j2HdPtKDoR7DunUvHd5_GCz6qh52TqWm8H7I8DssQ0Jex_zi1Nag6js7K4PjuYc20jJZR_3pZuYyE-uGeJ_TvkLYPyPnQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73406333</pqid></control><display><type>article</type><title>High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensives</title><source>ScienceDirect Journals</source><creator>Pitiriga, Vassiliki C. ; Kotsis, Vasilios T. ; Papamichail, Christos M. ; Alexandrou, Maria-Eleni K. ; Lekakis, John P. ; Kokolakis, Nikos ; Petrocheilou-Paschou, Vassiliky D. ; Zakopoulos, Nikos A.</creator><creatorcontrib>Pitiriga, Vassiliki C. ; Kotsis, Vasilios T. ; Papamichail, Christos M. ; Alexandrou, Maria-Eleni K. ; Lekakis, John P. ; Kokolakis, Nikos ; Petrocheilou-Paschou, Vassiliky D. ; Zakopoulos, Nikos A.</creatorcontrib><description>Previous studies have linked essential sustained hypertension with
Chlamydia pneumoniae (
C. pneumoniae) and changes in intima-media thickness (IMT) of carotid arteries. The aim of this study was to examine if similar associations exist in subjects with white-coat hypertension.
C. pneumoniae IgA and IgG antibody titers were measured in 125 patients with white-coat hypertension and 54 normotensives. All participants underwent a 24 h ambulatory blood pressure (BP) monitoring, clinic BP readings and common-internal carotid artery IMT measurements. Seventy subjects of the white-coat group (56%) and 15 of the control group (27.8%) had IgG titers ≥80 (crosstabs;
P<0.001). IgA titers were elevated in 75 subjects of the white-coat group (60%) and 10 (18.5%) of the control group (crosstabs;
P<0.001). The IMT of the carotid arteries in the white-coat group was significantly higher than that of the normotensive group (
t-test;
P<0.001 and
P<0.001, respectively). In contrast, carotid IMT did not differ between
C. pneumoniae-seropositive and
C. pneumoniae-seronegative groups concerning both IgG and IgA antibody titers. Our findings suggest that both
C. pneumoniae antibody titers and carotid IMT were increased in subjects with white-coat hypertension. The preceding associations strengthen prior evidence in favor of the opinion that white-coat hypertension is not an innocent phenomenon.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(02)00426-4</identifier><identifier>PMID: 12818405</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Antibodies, Bacterial - analysis ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure Determination - methods ; Blood Pressure Monitoring, Ambulatory ; C. pneumoniae infection ; Cardiology. Vascular system ; Carotid Arteries - diagnostic imaging ; Carotid Arteries - physiopathology ; Case-Control Studies ; Chlamydophila Infections - diagnosis ; Chlamydophila Infections - epidemiology ; Chlamydophila pneumoniae - immunology ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Humans ; Hypertension - diagnosis ; Hypertension - epidemiology ; Hypertension - immunology ; Intima-media thickness ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Probability ; Reference Values ; Risk Factors ; Sampling Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Tunica Intima - microbiology ; Tunica Intima - pathology ; Ultrasonography, Doppler ; White-coat hypertension</subject><ispartof>Atherosclerosis, 2003-04, Vol.167 (2), p.231-235</ispartof><rights>2003 Elsevier Science Ireland Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-64934d79cae8829c65d232e60fefc591aca6a70330ae66f8a8cdf096f1564b933</citedby><cites>FETCH-LOGICAL-c391t-64934d79cae8829c65d232e60fefc591aca6a70330ae66f8a8cdf096f1564b933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14660259$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12818405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pitiriga, Vassiliki C.</creatorcontrib><creatorcontrib>Kotsis, Vasilios T.</creatorcontrib><creatorcontrib>Papamichail, Christos M.</creatorcontrib><creatorcontrib>Alexandrou, Maria-Eleni K.</creatorcontrib><creatorcontrib>Lekakis, John P.</creatorcontrib><creatorcontrib>Kokolakis, Nikos</creatorcontrib><creatorcontrib>Petrocheilou-Paschou, Vassiliky D.</creatorcontrib><creatorcontrib>Zakopoulos, Nikos A.</creatorcontrib><title>High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensives</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Previous studies have linked essential sustained hypertension with
Chlamydia pneumoniae (
C. pneumoniae) and changes in intima-media thickness (IMT) of carotid arteries. The aim of this study was to examine if similar associations exist in subjects with white-coat hypertension.
C. pneumoniae IgA and IgG antibody titers were measured in 125 patients with white-coat hypertension and 54 normotensives. All participants underwent a 24 h ambulatory blood pressure (BP) monitoring, clinic BP readings and common-internal carotid artery IMT measurements. Seventy subjects of the white-coat group (56%) and 15 of the control group (27.8%) had IgG titers ≥80 (crosstabs;
P<0.001). IgA titers were elevated in 75 subjects of the white-coat group (60%) and 10 (18.5%) of the control group (crosstabs;
P<0.001). The IMT of the carotid arteries in the white-coat group was significantly higher than that of the normotensive group (
t-test;
P<0.001 and
P<0.001, respectively). In contrast, carotid IMT did not differ between
C. pneumoniae-seropositive and
C. pneumoniae-seronegative groups concerning both IgG and IgA antibody titers. Our findings suggest that both
C. pneumoniae antibody titers and carotid IMT were increased in subjects with white-coat hypertension. The preceding associations strengthen prior evidence in favor of the opinion that white-coat hypertension is not an innocent phenomenon.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Bacterial - analysis</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure Determination - methods</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>C. pneumoniae infection</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Arteries - physiopathology</subject><subject>Case-Control Studies</subject><subject>Chlamydophila Infections - diagnosis</subject><subject>Chlamydophila Infections - epidemiology</subject><subject>Chlamydophila pneumoniae - immunology</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - immunology</subject><subject>Intima-media thickness</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Risk Factors</subject><subject>Sampling Studies</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Tunica Intima - microbiology</subject><subject>Tunica Intima - pathology</subject><subject>Ultrasonography, Doppler</subject><subject>White-coat hypertension</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0E1vEzEQgGELgdq09CdQ7QVUDgvjj_XapwpFQJEqONCerYl33Ljar9qboPx7Nk1Ej5zm8ow9ehl7x-ETB64__wYQvLS8gisQHwGU0KV6xRbc1LbkyqjXbPGPnLKznB9hVjU3J-yUC8ONgmrBft7Eh3UxJtpiS72nYgjFct1it2siFmNPm27oI1KB_RRXQxMpF7Ev_qzjRKUfcCrWu5HSRH2OW8pv2ZuAbaaL4zxn99--3i1vyttf338sv9yWXlo-lVpZqZraeiRjhPW6aoQUpCFQ8JXl6FFjDVICktbBoPFNAKsDr7RaWSnP2YfDu2ManjaUJ9fF7Kltsadhk10tFWgp97A6QJ-GnBMFN6bYYdo5Dm4f0j2HdPtKDoR7DunUvHd5_GCz6qh52TqWm8H7I8DssQ0Jex_zi1Nag6js7K4PjuYc20jJZR_3pZuYyE-uGeJ_TvkLYPyPnQ</recordid><startdate>20030401</startdate><enddate>20030401</enddate><creator>Pitiriga, Vassiliki C.</creator><creator>Kotsis, Vasilios T.</creator><creator>Papamichail, Christos M.</creator><creator>Alexandrou, Maria-Eleni K.</creator><creator>Lekakis, John P.</creator><creator>Kokolakis, Nikos</creator><creator>Petrocheilou-Paschou, Vassiliky D.</creator><creator>Zakopoulos, Nikos A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030401</creationdate><title>High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensives</title><author>Pitiriga, Vassiliki C. ; Kotsis, Vasilios T. ; Papamichail, Christos M. ; Alexandrou, Maria-Eleni K. ; Lekakis, John P. ; Kokolakis, Nikos ; Petrocheilou-Paschou, Vassiliky D. ; Zakopoulos, Nikos A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-64934d79cae8829c65d232e60fefc591aca6a70330ae66f8a8cdf096f1564b933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Bacterial - analysis</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure Determination - methods</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>C. pneumoniae infection</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Arteries - physiopathology</topic><topic>Case-Control Studies</topic><topic>Chlamydophila Infections - diagnosis</topic><topic>Chlamydophila Infections - epidemiology</topic><topic>Chlamydophila pneumoniae - immunology</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - immunology</topic><topic>Intima-media thickness</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Probability</topic><topic>Reference Values</topic><topic>Risk Factors</topic><topic>Sampling Studies</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Tunica Intima - microbiology</topic><topic>Tunica Intima - pathology</topic><topic>Ultrasonography, Doppler</topic><topic>White-coat hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pitiriga, Vassiliki C.</creatorcontrib><creatorcontrib>Kotsis, Vasilios T.</creatorcontrib><creatorcontrib>Papamichail, Christos M.</creatorcontrib><creatorcontrib>Alexandrou, Maria-Eleni K.</creatorcontrib><creatorcontrib>Lekakis, John P.</creatorcontrib><creatorcontrib>Kokolakis, Nikos</creatorcontrib><creatorcontrib>Petrocheilou-Paschou, Vassiliky D.</creatorcontrib><creatorcontrib>Zakopoulos, Nikos A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pitiriga, Vassiliki C.</au><au>Kotsis, Vasilios T.</au><au>Papamichail, Christos M.</au><au>Alexandrou, Maria-Eleni K.</au><au>Lekakis, John P.</au><au>Kokolakis, Nikos</au><au>Petrocheilou-Paschou, Vassiliky D.</au><au>Zakopoulos, Nikos A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensives</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2003-04-01</date><risdate>2003</risdate><volume>167</volume><issue>2</issue><spage>231</spage><epage>235</epage><pages>231-235</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Previous studies have linked essential sustained hypertension with
Chlamydia pneumoniae (
C. pneumoniae) and changes in intima-media thickness (IMT) of carotid arteries. The aim of this study was to examine if similar associations exist in subjects with white-coat hypertension.
C. pneumoniae IgA and IgG antibody titers were measured in 125 patients with white-coat hypertension and 54 normotensives. All participants underwent a 24 h ambulatory blood pressure (BP) monitoring, clinic BP readings and common-internal carotid artery IMT measurements. Seventy subjects of the white-coat group (56%) and 15 of the control group (27.8%) had IgG titers ≥80 (crosstabs;
P<0.001). IgA titers were elevated in 75 subjects of the white-coat group (60%) and 10 (18.5%) of the control group (crosstabs;
P<0.001). The IMT of the carotid arteries in the white-coat group was significantly higher than that of the normotensive group (
t-test;
P<0.001 and
P<0.001, respectively). In contrast, carotid IMT did not differ between
C. pneumoniae-seropositive and
C. pneumoniae-seronegative groups concerning both IgG and IgA antibody titers. Our findings suggest that both
C. pneumoniae antibody titers and carotid IMT were increased in subjects with white-coat hypertension. The preceding associations strengthen prior evidence in favor of the opinion that white-coat hypertension is not an innocent phenomenon.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>12818405</pmid><doi>10.1016/S0021-9150(02)00426-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Atherosclerosis, 2003-04, Vol.167 (2), p.231-235 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adult Aged Antibodies, Bacterial - analysis Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure Determination - methods Blood Pressure Monitoring, Ambulatory C. pneumoniae infection Cardiology. Vascular system Carotid Arteries - diagnostic imaging Carotid Arteries - physiopathology Case-Control Studies Chlamydophila Infections - diagnosis Chlamydophila Infections - epidemiology Chlamydophila pneumoniae - immunology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Humans Hypertension - diagnosis Hypertension - epidemiology Hypertension - immunology Intima-media thickness Male Medical sciences Middle Aged Prevalence Probability Reference Values Risk Factors Sampling Studies Sensitivity and Specificity Severity of Illness Index Tunica Intima - microbiology Tunica Intima - pathology Ultrasonography, Doppler White-coat hypertension |
| title | High prevalence of Chlamydia pneumoniae antibodies in white-coat hypertensives |
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