Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates

More than mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one‐step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-09, Vol.48 (41), p.7560-7563
Main Authors: Roth, Anke G, Drescher, Daniela, Yang, Yang, Redmer, Susanne, Uhlig, Stefan, Arenz, Christoph
Format: Article
Language:English
Subjects:
Animals
Apoptosis
bioorganic chemistry
bisphosphonates
Cells, Cultured
Diphosphonates - chemical synthesis
Diphosphonates - chemistry
Diphosphonates - metabolism
drug targets
enzyme inhibitors
Female
Humans
Isoenzymes - antagonists & inhibitors
Isoenzymes - metabolism
Molecular Structure
Rats
Rats, Wistar
sphingolipids
Sphingomyelin Phosphodiesterase - antagonists & inhibitors
Sphingomyelin Phosphodiesterase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433
cites cdi_FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433
container_end_page 7563
container_issue 41
container_start_page 7560
container_title Angewandte Chemie (International ed.)
container_volume 48
creator Roth, Anke G
Drescher, Daniela
Yang, Yang
Redmer, Susanne
Uhlig, Stefan
Arenz, Christoph
description More than mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one‐step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for inflammatory lung diseases, bisphosphonates may find application in the treatment of pulmonary diseases.
doi_str_mv 10.1002/anie.200903288
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734063509</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734063509</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433</originalsourceid><addsrcrecordid>eNqFkM9P2zAYhi3EBIztyhFy45TOPxr787EUBhUIJnUIbpaTfqGG1C5xuq3__VylAm4cLFvy8z7-_BJyxOiAUcp_WO9wwCnVVHCAHXLACs5yoZTYTeehELmCgu2TrzE-Jx6Ayj2yz7QaSqH0Abn-FTr0XWb9LJtig1Xn_mA28XNXus4Fn4U6G1UuXS7nzj-FxRob523ErFxnZy4u52GzvO0wfiNfattE_L7dD8n9z4vf46v85u5yMh7d5NWQSsg110MBBa-qmhVW1TLNVWiGeiZLAIQ0vOZYzGRdgmVWaiitBsm5lIB1-tIhOe29yza8rjB2ZuFihU1jPYZVNEqkd0RBdSIHPVm1IcYWa7Ns3cK2a8Oo2fRnNv2Zt_5S4HirXpULnL3j28ISoHvgr2tw_YnOjG4nFx_leZ91scN_b1nbvhiphCrMw-2lOYep5PD4YGjiT3q-tsHYp9ZFcz_llAnKJCiWjP8BmySUAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734063509</pqid></control><display><type>article</type><title>Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates</title><source>Wiley</source><creator>Roth, Anke G ; Drescher, Daniela ; Yang, Yang ; Redmer, Susanne ; Uhlig, Stefan ; Arenz, Christoph</creator><creatorcontrib>Roth, Anke G ; Drescher, Daniela ; Yang, Yang ; Redmer, Susanne ; Uhlig, Stefan ; Arenz, Christoph</creatorcontrib><description>More than mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one‐step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for inflammatory lung diseases, bisphosphonates may find application in the treatment of pulmonary diseases.</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.200903288</identifier><identifier>PMID: 19746379</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>Animals ; Apoptosis ; bioorganic chemistry ; bisphosphonates ; Cells, Cultured ; Diphosphonates - chemical synthesis ; Diphosphonates - chemistry ; Diphosphonates - metabolism ; drug targets ; enzyme inhibitors ; Female ; Humans ; Isoenzymes - antagonists &amp; inhibitors ; Isoenzymes - metabolism ; Molecular Structure ; Rats ; Rats, Wistar ; sphingolipids ; Sphingomyelin Phosphodiesterase - antagonists &amp; inhibitors ; Sphingomyelin Phosphodiesterase - metabolism</subject><ispartof>Angewandte Chemie (International ed.), 2009-09, Vol.48 (41), p.7560-7563</ispartof><rights>Copyright © 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433</citedby><cites>FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19746379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roth, Anke G</creatorcontrib><creatorcontrib>Drescher, Daniela</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Redmer, Susanne</creatorcontrib><creatorcontrib>Uhlig, Stefan</creatorcontrib><creatorcontrib>Arenz, Christoph</creatorcontrib><title>Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates</title><title>Angewandte Chemie (International ed.)</title><addtitle>Angewandte Chemie International Edition</addtitle><description>More than mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one‐step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for inflammatory lung diseases, bisphosphonates may find application in the treatment of pulmonary diseases.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>bioorganic chemistry</subject><subject>bisphosphonates</subject><subject>Cells, Cultured</subject><subject>Diphosphonates - chemical synthesis</subject><subject>Diphosphonates - chemistry</subject><subject>Diphosphonates - metabolism</subject><subject>drug targets</subject><subject>enzyme inhibitors</subject><subject>Female</subject><subject>Humans</subject><subject>Isoenzymes - antagonists &amp; inhibitors</subject><subject>Isoenzymes - metabolism</subject><subject>Molecular Structure</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>sphingolipids</subject><subject>Sphingomyelin Phosphodiesterase - antagonists &amp; inhibitors</subject><subject>Sphingomyelin Phosphodiesterase - metabolism</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkM9P2zAYhi3EBIztyhFy45TOPxr787EUBhUIJnUIbpaTfqGG1C5xuq3__VylAm4cLFvy8z7-_BJyxOiAUcp_WO9wwCnVVHCAHXLACs5yoZTYTeehELmCgu2TrzE-Jx6Ayj2yz7QaSqH0Abn-FTr0XWb9LJtig1Xn_mA28XNXus4Fn4U6G1UuXS7nzj-FxRob523ErFxnZy4u52GzvO0wfiNfattE_L7dD8n9z4vf46v85u5yMh7d5NWQSsg110MBBa-qmhVW1TLNVWiGeiZLAIQ0vOZYzGRdgmVWaiitBsm5lIB1-tIhOe29yza8rjB2ZuFihU1jPYZVNEqkd0RBdSIHPVm1IcYWa7Ns3cK2a8Oo2fRnNv2Zt_5S4HirXpULnL3j28ISoHvgr2tw_YnOjG4nFx_leZ91scN_b1nbvhiphCrMw-2lOYep5PD4YGjiT3q-tsHYp9ZFcz_llAnKJCiWjP8BmySUAA</recordid><startdate>20090928</startdate><enddate>20090928</enddate><creator>Roth, Anke G</creator><creator>Drescher, Daniela</creator><creator>Yang, Yang</creator><creator>Redmer, Susanne</creator><creator>Uhlig, Stefan</creator><creator>Arenz, Christoph</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090928</creationdate><title>Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates</title><author>Roth, Anke G ; Drescher, Daniela ; Yang, Yang ; Redmer, Susanne ; Uhlig, Stefan ; Arenz, Christoph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>bioorganic chemistry</topic><topic>bisphosphonates</topic><topic>Cells, Cultured</topic><topic>Diphosphonates - chemical synthesis</topic><topic>Diphosphonates - chemistry</topic><topic>Diphosphonates - metabolism</topic><topic>drug targets</topic><topic>enzyme inhibitors</topic><topic>Female</topic><topic>Humans</topic><topic>Isoenzymes - antagonists &amp; inhibitors</topic><topic>Isoenzymes - metabolism</topic><topic>Molecular Structure</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>sphingolipids</topic><topic>Sphingomyelin Phosphodiesterase - antagonists &amp; inhibitors</topic><topic>Sphingomyelin Phosphodiesterase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roth, Anke G</creatorcontrib><creatorcontrib>Drescher, Daniela</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Redmer, Susanne</creatorcontrib><creatorcontrib>Uhlig, Stefan</creatorcontrib><creatorcontrib>Arenz, Christoph</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie (International ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roth, Anke G</au><au>Drescher, Daniela</au><au>Yang, Yang</au><au>Redmer, Susanne</au><au>Uhlig, Stefan</au><au>Arenz, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates</atitle><jtitle>Angewandte Chemie (International ed.)</jtitle><addtitle>Angewandte Chemie International Edition</addtitle><date>2009-09-28</date><risdate>2009</risdate><volume>48</volume><issue>41</issue><spage>7560</spage><epage>7563</epage><pages>7560-7563</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>More than mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one‐step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for inflammatory lung diseases, bisphosphonates may find application in the treatment of pulmonary diseases.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag</pub><pmid>19746379</pmid><doi>10.1002/anie.200903288</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1433-7851
ispartof Angewandte Chemie (International ed.), 2009-09, Vol.48 (41), p.7560-7563
issn 1433-7851
1521-3773
language eng
recordid cdi_proquest_miscellaneous_734063509
source Wiley
subjects Animals
Apoptosis
bioorganic chemistry
bisphosphonates
Cells, Cultured
Diphosphonates - chemical synthesis
Diphosphonates - chemistry
Diphosphonates - metabolism
drug targets
enzyme inhibitors
Female
Humans
Isoenzymes - antagonists & inhibitors
Isoenzymes - metabolism
Molecular Structure
Rats
Rats, Wistar
sphingolipids
Sphingomyelin Phosphodiesterase - antagonists & inhibitors
Sphingomyelin Phosphodiesterase - metabolism
title Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A41%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potent%20and%20Selective%20Inhibition%20of%20Acid%20Sphingomyelinase%20by%20Bisphosphonates&rft.jtitle=Angewandte%20Chemie%20(International%20ed.)&rft.au=Roth,%20Anke%20G&rft.date=2009-09-28&rft.volume=48&rft.issue=41&rft.spage=7560&rft.epage=7563&rft.pages=7560-7563&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.200903288&rft_dat=%3Cproquest_cross%3E734063509%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4068-92943852ccf15a7f6002591e9d6b88e837792e5d6fb8a1a698ba98622668ef433%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=734063509&rft_id=info:pmid/19746379&rfr_iscdi=true