What is Cooperativity

The lamprey holds the clue to the link between supramolecular self‐assembly and allosteric ligand binding. Chelate cooperativity in self‐assembled structures results in denaturation behavior that is indistinguishable from allosteric ligand binding. The chelate effect is the most common origin of pos...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-09, Vol.48 (41), p.7488-7499
Main Authors: Hunter, Christopher A, Anderson, Harry L
Format: Article
Language:English
Subjects:
allosteric cooperativity
chelate cooperativity
cooperative effects
self-assembly
supramolecular chemistry
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Summary:The lamprey holds the clue to the link between supramolecular self‐assembly and allosteric ligand binding. Chelate cooperativity in self‐assembled structures results in denaturation behavior that is indistinguishable from allosteric ligand binding. The chelate effect is the most common origin of positive cooperativity, yet its significance has been widely overlooked.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200902490