Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification

Aims:  In this study, the appearance and distribution of neurofibrillary tangles (NFT) in diffuse neurofibrillary tangles with calcification (DNTC) were investigated neuropathologically in order to elucidate the detailed distribution pattern in this disease. Methods:  The distribution of NFT in six...

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Published in:Psychiatry and clinical neurosciences 2009-10, Vol.63 (5), p.646-651
Main Authors: Ukai, Katsuyuki, Shibayama, Hiroto, Ishihara, Ryoko, Ozaki, Norio
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cerebellum - pathology
Cerebral Cortex - pathology
dementia
diffuse neurofibrillary tangles with calcification (DNTC)
Diffuse Neurofibrillary Tangles with Calcification - pathology
distribution of neurofibrillary tangles
Female
Humans
Kosaka–Shibayama disease
Limbic System - pathology
Male
Medical sciences
Mesencephalon - pathology
Middle Aged
neurofibrillary tangles (NFT)
Neurofibrillary Tangles - pathology
Pons - pathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Aims:  In this study, the appearance and distribution of neurofibrillary tangles (NFT) in diffuse neurofibrillary tangles with calcification (DNTC) were investigated neuropathologically in order to elucidate the detailed distribution pattern in this disease. Methods:  The distribution of NFT in six cases neuropathologically diagnosed as DNTC (two men and four women) was studied using Gallyas–Braak silver stain. The age at death ranged from 56 to 73, with an average of 63.5 ± 7.5 years. Results:  NFT were seen throughout the cerebral cortex, and were especially marked in the temporal and limbic cortices. The distribution pattern of NFT in the limbic lobe was similar to that in Alzheimer's disease as reported in the previous studies. In the temporal lobe, more NFT were distributed in the anterior than in the posterior area, which was confirmed in all six cases. The temporal pole showed the highest density of NFT including ghost tangles. Conclusions:  The diffuse appearance of NFT in the cerebral cortex with the highest severity in the temporal pole was found to be a neuropathological characteristic of DNTC.
ISSN:1323-1316
1440-1819
DOI:10.1111/j.1440-1819.2009.02000.x