Segregation Analysis of Mandibular Prognathism in Libya

The etiology of mandibular prognathism has been attributed to various genetic inheritance patterns and some environmental factors. The variation in inheritance patterns can be partly due to the use of different statistical approaches in the respective studies. The objective of this study was to inve...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dental research 2003-07, Vol.82 (7), p.523-527
Main Authors: El-Gheriani, A.A., Maher, B.S., El-Gheriani, A.S., Sciote, J.J., Abu-shahba, F.A., Al-Azemi, R., Marazita, M.L.
Format: Article
Language:English
Subjects:
Adult
Cephalometry
Chromosome Segregation
Dentistry
Family Health
Female
Genes, Dominant
Humans
Libya
Likelihood Functions
Male
Malocclusion, Angle Class III - genetics
Mandible - abnormalities
Middle Aged
Models, Genetic
Prognathism - genetics
Quantitative Trait, Heritable
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The etiology of mandibular prognathism has been attributed to various genetic inheritance patterns and some environmental factors. The variation in inheritance patterns can be partly due to the use of different statistical approaches in the respective studies. The objective of this study was to investigate the role of genetic influences in the etiology of this trait. We performed segregation analysis on 37 families of patients currently being treated for mandibular prognathism. Mandibular prognathism was treated as a qualitative trait, with cephalometric radiographs, dental models, and photographs used to verify diagnosis. Segregation analysis of a prognathic mandible in the entire dataset supported a transmissible Mendelian major effect, with a dominant mode of inheritance determined to be the most parsimonious.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910308200707