Atelocollagen-associated autologous chondrocyte implantation for the repair of chondral defects of the knee: a prospective multicenter clinical trial in Japan

• Published in: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2009-09, Vol.14 (5), p.579-588
• Main Authors: Tohyama, H., Yasuda, K., Minami, A., Majima, T., Iwasaki, N., Muneta, T., Sekiya, I., Yagishita, K., Takahashi, S., Kurokouchi, K., Uchio, Y., Iwasa, J., Deie, M., Adachi, N., Sugawara, K., Ochi, M.
• Format: Article
• Language: English
• Subjects: Adult; Cartilage, Articular - injuries; Cartilage, Articular - surgery; Chondrocytes - transplantation; Collagen - therapeutic use; Female; Follow-Up Studies; Humans; Knee Injuries - complications; Knee Injuries - surgery; Male; Medicine; Medicine & Public Health; Original Article; Orthopedic Procedures - methods; Orthopedics; Osteoarthritis - surgery; Osteochondritis Dissecans - surgery; Recovery of Function; Rheumatology; Tissue Engineering - methods; Tissue Scaffolds; Transplantation, Autologous
• ISSN: 0949-2658; 1436-2023
• DOI: 10.1007/s00776-009-1384-1

New tissue-engineering technology was developed to create a cartilage-like tissue in a three-dimensional culture using atelocollagen gel. The minimum 2-year followup outcome of transplanting autologous chondrocytes cultured in atelocollagen gel for the treatment of full-thickness defects of cartilage in knees was reported from the single institution. The present multicenter study was conducted to determine clinical and arthroscopic outcomes in patients who underwent atelocollagen-associated autologous chondrocyte implantation for the repair of chondral defects of the knees. At six medical institutes in Japan, we prospectively evaluated the clinical and arthroscopic outcomes of transplanting autologous chondrocytes cultured in atelocollagen gel for the treatment of full-thickness defects of cartilage in 27 patients (27 knees) with cartilage lesions on a femoral condyle or on a patellar facet over 24 months. The Lysholm score significantly increased from 60.0 ± 13.7 points to 89.8 ± 9.5 points (P = 0.001). Concerning the ICRS grade for arthroscopic appearance, 6 knees (24%) were assessed as grade I (normal) and 17 knees (68%) as grade II (nearly normal). There were few adverse features, except for detachment of the graft in two cases. We concluded that transplanting chondrocytes in a newly formed matrix of atelocollagen gel can promote restoration of the articular cartilage of the knee.