Detecting lesions in multiple sclerosis at 4.7 tesla using phase susceptibility-weighting and T2-weighting

Purpose To demonstrate 4.7 Tesla (T) imaging methods for visualizing lesions in multiple sclerosis in the human brain using phase susceptibility‐weighting and T2 weighting. Materials and Methods Seven patients with relapsing‐remitting multiple sclerosis were imaged at 4.7T using three‐dimensional (3...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2009-10, Vol.30 (4), p.737-742
Main Authors: Eissa, Amir, Lebel, R. Marc, Korzan, Jeff R., Zavodni, Anna E., Warren, Kenneth G., Catz, Ingrid, Emery, Derek J., Wilman, Alan H.
Format: Article
Language:English
Subjects:
4.7T
Adult
Brain - pathology
fast spin echo
Female
high field
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - pathology
phase imaging
susceptibility-weighted imaging
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Summary:Purpose To demonstrate 4.7 Tesla (T) imaging methods for visualizing lesions in multiple sclerosis in the human brain using phase susceptibility‐weighting and T2 weighting. Materials and Methods Seven patients with relapsing‐remitting multiple sclerosis were imaged at 4.7T using three‐dimensional (3D) susceptibility‐weighted imaging (SWI) with 0.90 mm3 voxel volumes, and with 2D T2‐weighted fast spin echo (T2WFSE) with 0.34 mm3 voxels and 1.84 mm3 voxels. The visibility of MS lesions at 4.7T with phase SWI and T2WFSE was assessed by independent lesion counts made by an experienced neuroradiologist, and by quantitative measures. Results High resolution T2WFSE at 4.7T provided excellent depiction of hyperintense lesions. When combined with phase SWI, 124 total lesions were identified of which 18% were only visible on phase SWI and not on T2WFSE. The phase lesions had a mean phase shift relative to local background of −11.15 ± 5.97 parts per billion. Conclusion Imaging at 4.7T can provide both high quality, high resolution T2WFSE and SWI for visualization of lesions in multiple sclerosis. Phase susceptibility‐weighting can identify additional lesions that are not visible with high resolution T2WFSE. J. Magn. Reson. Imaging 2009;30:737–742. © 2009 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.21926