HLA-B8, DR3: a new risk factor for graft failure after renal transplantation in patients with underlying immunoglobulin A nephropathy

:  Background:  The HLA‐B8, DR3 haplotype has been associated with high immune reactivity. In this study, we have tested whether this haplotype has differential effect on graft survival in patients with IgAN compared with control patients. Methods:  From the Eurotransplant Registry we analyzed graft...

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Bibliographic Details
Published in:Clinical transplantation 2009-09, Vol.23 (5), p.660-665
Main Authors: Andresdottir, Margret B., Haasnoot, Geert W., Persijn, Guido G., Claas, Frans H.J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
DR3
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
Genotype
Glomerulonephritis, IGA - genetics
Glomerulonephritis, IGA - surgery
Graft Rejection - genetics
Graft Rejection - immunology
graft survival
Haplotypes - genetics
HLA-B8
HLA-B8 Antigen - genetics
HLA-B8 Antigen - immunology
Humans
IgA nephropathy
IgAN
Kidney Transplantation
Male
Medical sciences
Middle Aged
Phenotype
Prognosis
Public health. Hygiene
Public health. Hygiene-occupational medicine
Receptors, Tumor Necrosis Factor, Member 25 - genetics
Receptors, Tumor Necrosis Factor, Member 25 - immunology
Registries
renal transplantation
risk factor
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Survival Rate
Tissue, organ and graft immunology
Treatment Outcome
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Summary::  Background:  The HLA‐B8, DR3 haplotype has been associated with high immune reactivity. In this study, we have tested whether this haplotype has differential effect on graft survival in patients with IgAN compared with control patients. Methods:  From the Eurotransplant Registry we analyzed graft survival of 1207 recipients with IgAN and 7935 control patients with non‐glomerular diseases. Death‐censored graft loss according to the HLA‐B8, DR3 haplotype was calculated with Kaplan–Meier analysis and Cox‐regression model was used to correct for various risk factors. Results:  The frequency of the HLA‐B8, DR3 haplotype was significantly lower in IgAN patients compared with controls (10.3% vs. 15.4%, p 
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2009.01059.x