Ginsenoside Rh2 Ameliorates Scopolamine-Induced Learning Deficit in Mice

To understand memory-enhancing effect of red ginseng biotransformed by Bifidobacterium longum H-1 (RGB), which more potently improved scopolamine-induced learning deficit than red ginseng in the preliminary experiment, its main constituents, ginsenosides Rb1, Rg3 and Rh2, were isolated and their mem...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2009/10/01, Vol.32(10), pp.1710-1715
Main Authors: Yang, Jung-Hwa, Han, Sang-Jun, Ryu, Jong Hoon, Jang, Il-Sung, Kim, Dong-Hyun
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Bifidobacterium
Bifidobacterium longum
Biotransformation
Disease Models, Animal
ginsenoside Rh2
Ginsenosides - isolation & purification
Ginsenosides - pharmacology
Ginsenosides - therapeutic use
long-term potentiation
Maze Learning - drug effects
memory
Memory Disorders - chemically induced
Memory Disorders - drug therapy
Mice
Mice, Inbred ICR
Panax - chemistry
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
red ginseng
Scopolamine
Swimming
Synaptic Potentials
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Summary:To understand memory-enhancing effect of red ginseng biotransformed by Bifidobacterium longum H-1 (RGB), which more potently improved scopolamine-induced learning deficit than red ginseng in the preliminary experiment, its main constituents, ginsenosides Rb1, Rg3 and Rh2, were isolated and their memory-enhancing effects investigated in scopolamine-treated mice by using passive avoidance and Y-maze tests. Among them, ginsenoside Rh2 most potently reversed memory impairment caused by scopolamine. Ginsenoside Rh2 also significantly shortened the escape latencies prolonged by scopolamine in the Morris water maze test (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.32.1710