Non-Hodgkin's lymphoma and hepatitis C virus infection

The authors report four cases of non Hodgkin's lymphomas (NHL) among patients infected by the hepatitis C virus (HCV). They discuss the epidemiological, physiopathological and clinical features of this association. The role of the HCV in the development of B-cell NHL is probable but the reporte...

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Bibliographic Details
Published in:La revue de medecine interne 2003-07, Vol.24 (7), p.452-458
Main Authors: Ennibi, K, Bechade, D, Rabhi, M, Coutant, G, Toloune, F, Desrame, J, Archane, M-I, Algayres, J-P
Format: Article
Language:fre
Subjects:
Female
Hepacivirus - pathogenicity
Hepatitis C - complications
Humans
Lymphoma, Non-Hodgkin - epidemiology
Lymphoma, Non-Hodgkin - pathology
Lymphoma, Non-Hodgkin - virology
Magnetic Resonance Imaging
Male
Middle Aged
Tomography, X-Ray Computed
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Summary:The authors report four cases of non Hodgkin's lymphomas (NHL) among patients infected by the hepatitis C virus (HCV). They discuss the epidemiological, physiopathological and clinical features of this association. The role of the HCV in the development of B-cell NHL is probable but the reported frequency of the association with HCV infection is variable especially in different countries. Most of the reported cases are low-grade NHL with frequent extranodal involvement. New studies will improve the understanding of the physiopathological mechanisms that might explain the occurrence of NHL in the course of HCV infection. The recent evidence that the antiviral treatment is effective in splenic lymphoma with villous lymphocytes leads to reconsider the relationship between HCV and NHL and to think about new therapeutic possibilities.
ISSN:0248-8663
DOI:10.1016/S0248-8663(03)00106-1