Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer

Purpose Survivin has been shown to be an important mediator of cellular radioresistance in vitro. This study aims to compare survivin expression and apoptosis to histomorphologic responses to neoadjuvant radiochemotherapy (RCT) in rectal cancer. Materials and methods Thirty-six pre-treatment biopsie...

Full description

Saved in:
Bibliographic Details
Published in:International journal of colorectal disease 2009-11, Vol.24 (11), p.1261-1269
Main Authors: McDowell, Dermot T, Smith, Fraser M, Reynolds, John V, Maher, Stephen G, Adida, Collette, Crotty, Paul, Gaffney, Eoin F, Hollywood, Donal, Mehigan, Brian, Stephens, Richard B, Kennedy, M. J
Format: Article
Language:English
Subjects:
Apoptosis
Biological and medical sciences
Biopsy
Cell Proliferation
Chemotherapy, Adjuvant
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression Regulation, Neoplastic
Hepatology
Humans
Inhibitor of Apoptosis Proteins
Internal Medicine
Ki-67 Antigen - metabolism
Lymph Nodes - pathology
Medical sciences
Medicine
Medicine & Public Health
Microtubule-Associated Proteins - metabolism
Neoadjuvant Therapy
Neoplasm Staging
Original Article
Proctology
Radiotherapy, Adjuvant
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
Staining and Labeling
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Survivin has been shown to be an important mediator of cellular radioresistance in vitro. This study aims to compare survivin expression and apoptosis to histomorphologic responses to neoadjuvant radiochemotherapy (RCT) in rectal cancer. Materials and methods Thirty-six pre-treatment biopsies were studied. Survivin mRNA and protein expression plus TUNEL staining for apoptosis was performed. Response to treatment was assessed using a 5-point tumour regression grade. Results Survivin expression was not found to be predictive of response to RCT (p = NS). In contrast, spontaneous apoptosis was significantly (p = 0.0051) associated with subsequent response to RCT. However, no association between survivin expression and levels of apoptosis could be identified. Conclusions This in vivo study failed to support in vitro studies showing an association between survivin and response to chemotherapy and radiation therapy. These results caution against the translation of the in vitro properties of survivin into a clinical setting.
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-009-0755-6