Oral Streptococcus species in pre-term and full-term children - a longitudinal study

Background.  Despite high clinical significance, the microbiology of the dental biofilm in young children remains poorly understood. Aim.  The aim of this longitudinal study was to investigate five Streptoccocus species commonly found in the oral biofilm of children, namely Streptococcus mutans, Str...

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Published in:International journal of paediatric dentistry 2009-11, Vol.19 (6), p.406-411
Main Authors: KIM SEOW, W., LAM, JANICE H. C., TSANG, ANNETTA K. L., HOLCOMBE, TREVOR, BIRD, PHILIP S.
Format: Article
Language:English
Subjects:
Case-Control Studies
Child, Preschool
Colony Count, Microbial
Dental Plaque - microbiology
Dentistry
DNA, Bacterial - analysis
Humans
Infant
Infant, Newborn
Infant, Premature
Longitudinal Studies
Pilot Projects
Saliva - microbiology
Streptococcus - isolation & purification
Streptococcus mitis
Streptococcus mutans
Streptococcus salivarius
Streptococcus sanguinis
Streptococcus sobrinus
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Summary:Background.  Despite high clinical significance, the microbiology of the dental biofilm in young children remains poorly understood. Aim.  The aim of this longitudinal study was to investigate five Streptoccocus species commonly found in the oral biofilm of children, namely Streptococcus mutans, Streptococcus sobrinus, Streptococcus mitis, Streptococcus sanguinis, and Streptococcus salivarius to determine their relative numbers in caries‐free pre‐term children, and age‐matched full‐term controls. Design.  Plaque and saliva samples were obtained from 15 pre‐term children and 15 age‐matched controls at ages 3, 6, 12, 18, and 24 months. A quantitative real‐time PCR technique was used to determine the numbers of five species of Streptococcus using probes and primers specific for each bacterial species. Results.  All species of Streptococcus generally increased from ages 3 to 24 months. The relative ratios of the bacteria remained fairly constant at all ages studied (P > 0.1). There were no significant differences in numbers of all Streptococcus species between pre‐term children and full‐term controls at all the ages investigated between. Conclusion.  The results show that the relative numbers of S. mutans, S. sobrinus, S. mitis, S. sanguinis, and S. salivarius remain relatively constant from 3 to 24 months of age in caries‐free pre‐ and full‐term children.
ISSN:0960-7439
1365-263X
DOI:10.1111/j.1365-263X.2009.01003.x