Antioxidant and antibacterial studies of arylazopyrazoles and arylhydrazonopyrazolones containing coumarin moiety

A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showe...

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Bibliographic Details
Published in:European journal of medicinal chemistry 2009-11, Vol.44 (11), p.4690-4694
Main Authors: Manojkumar, P., Ravi, T.K., Gopalakrishnan, S.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antioxidant
Antioxidants - chemistry
Antioxidants - pharmacology
Bacillus subtilis - drug effects
Biological and medical sciences
Coumarins - chemistry
Coumarins - pharmacology
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Medical sciences
Pharmacology. Drug treatments
Pyrazole
Pyrazoles - chemistry
Pyrazoles - pharmacology
Pyrazolones - chemistry
Pyrazolones - pharmacology
Staphylococcus aureus - drug effects
Structure-Activity Relationship
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Summary:A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showed good antibacterial activity and compound 5e was found to be the most active antioxidant in the series, and thus represent a new class of promising lead compounds. [Display omitted]
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2009.07.004