Symptoms and signs of syncope: a review of the link between physiology and clinical clues

Detailed history taking is of paramount importance to establish a reliable diagnosis in patients with transient loss of consciousness. In this article the clinical symptoms and signs of the successive phases of a syncopal episode are reviewed. A failure of the systemic circulation to perfuse the bra...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 2009-10, Vol.132 (10), p.2630-2642
Main Authors: Wieling, Wouter, Thijs, Roland D., van Dijk, N., Wilde, Arthur A. M., Benditt, David G., van Dijk, J. Gert
Format: Article
Language:English
Subjects:
Acceleration
Apnea - physiopathology
Biological and medical sciences
blood pressure
cerebral blood flow
Consciousness - physiology
Electroencephalography
Flushing - physiopathology
Humans
Hypotension, Orthostatic - physiopathology
Hypoxia - complications
Medical sciences
Neck - physiology
Neurology
reflex
Reflex - physiology
Seizures - etiology
Seizures - physiopathology
syncope
Syncope - diagnosis
Syncope - physiopathology
Syncope, Vasovagal - physiopathology
Tumors of the nervous system. Phacomatoses
vasovagal
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Summary:Detailed history taking is of paramount importance to establish a reliable diagnosis in patients with transient loss of consciousness. In this article the clinical symptoms and signs of the successive phases of a syncopal episode are reviewed. A failure of the systemic circulation to perfuse the brain sufficiently results in a stereotyped progression of neurological symptoms and signs culminating in loss of consciousness; when transient, this is syncope. Prior to loss of consciousness the affected individual tends to exhibit unclear thinking, followed by fixation of the eyes in the midline and a ‘frozen’ appearance. Narrowing of the field of vision with loss of colour vision (‘greying’ out) and finally a complete loss of vision (hence ‘blacking’ out) occurs. Hearing loss may occur following loss of vision. This process may take as little as ∼7 s in cases of sudden complete circulatory arrest (e.g. abrupt asystole), but in other circumstances it may take longer depending on the rate and depth of cerebral hypoperfusion. Complete loss of consciousness occurs with the ‘turning up’ of the eyeballs. Profound cerebral hypoperfusion may be accompanied by myoclonic jerks.
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/awp179