Biotechnological production of 2,3-butanediol—Current state and prospects

Biotechnological production of 2,3-butanediol (hereafter referred to as 2,3-BD) from wastes and excessive biomass is a promising and attractive alternative for traditional chemical synthesis. In the face of scarcity of fossil fuel supplies the bio-based process is receiving a significant interest, s...

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Bibliographic Details
Published in:Biotechnology advances 2009-11, Vol.27 (6), p.715-725
Main Authors: Celińska, E., Grajek, W.
Format: Article
Language:English
Subjects:
2,3-butanediol
Bio-based chemicals
Biological and medical sciences
Biomass
Biomass conversion
Biotechnology
Butylene Glycols - metabolism
Coculture Techniques
Fundamental and applied biological sciences. Psychology
Pilot Projects
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Summary:Biotechnological production of 2,3-butanediol (hereafter referred to as 2,3-BD) from wastes and excessive biomass is a promising and attractive alternative for traditional chemical synthesis. In the face of scarcity of fossil fuel supplies the bio-based process is receiving a significant interest, since 2,3-BD may have multiple practical applications (e.g. production of synthetic rubber, plasticizers, fumigants, as an antifreeze agent, fuel additive, octane booster, and many others). Although the 2,3-BD pathway is well known, microorganisms able to ferment biomass to 2,3-BD have been isolated and described, and attempts of pilot scale production of this compound were made, still much has to be done in order to achieve desired profitability. This review summarizes hitherto gained knowledge and experience in biotechnological production of 2,3-BD, sources of biomass used, employed microorganisms both wild type and genetically improved strains, as well as operating conditions applied.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2009.05.002