Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative bearing a lysine moiety

A planar catechin derivative incorporating a lysine moiety was synthesized and showed approximately 400-fold increased radical-scavenging activity relative to naturally-occurring (+)-catechin.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2009-11 (41), p.6180-6182
Main Authors: Fukuhara, Kiyoshi, Nakanishi, Ikuo, Ohkubo, Kei, Obara, Yoshinori, Tada, Ayako, Imai, Kohei, Ohno, Akiko, Nakamura, Asao, Ozawa, Toshihiko, Urano, Shiro, Saito, Shinichi, Fukuzumi, Shunichi, Anzai, Kazunori, Miyata, Naoki, Okuda, Haruhiro
Format: Article
Language:English
Subjects:
Catechin - analogs & derivatives
Free Radical Scavengers - chemical synthesis
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Lysine - chemistry
Models, Molecular
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Description
Summary:A planar catechin derivative incorporating a lysine moiety was synthesized and showed approximately 400-fold increased radical-scavenging activity relative to naturally-occurring (+)-catechin.
ISSN:1364-548X
DOI:10.1039/b913714a