Blood flow rate measurements with indicator techniques revisited

Summary In view of the emerging role, disturbances in regional blood flow rate seem to play in the pathogenesis of the metabolic syndrome; we review the concepts of the classical indicator dilution and washout techniques used for determinations of regional blood flow rate. Prerequisites, assumptions...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2009-11, Vol.29 (6), p.385-391
Main Authors: Sejrsen, Per, Bülow, Jens
Format: Article
Language:English
Subjects:
Algorithms
assumptions
Biological and medical sciences
blood flow rate
Blood Flow Velocity - physiology
cardiac output
Computer Simulation
Diagnosis, Computer-Assisted - methods
Fundamental and applied biological sciences. Psychology
heat as indicator
Humans
Indicator Dilution Techniques
indicator kinetics
indicators
Models, Cardiovascular
Regional Blood Flow - physiology
regional distribution volume
Rheology - methods
Vertebrates: anatomy and physiology, studies on body, several organs or systems
washout rate
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Summary:Summary In view of the emerging role, disturbances in regional blood flow rate seem to play in the pathogenesis of the metabolic syndrome; we review the concepts of the classical indicator dilution and washout techniques used for determinations of regional blood flow rate. Prerequisites, assumptions, necessary precautions for the application of these experimental techniques are emphasized. Special attention has been carried out to elucidate the consequence of a choice of indicators having a large distribution volume in the tissues.
ISSN:1475-0961
1475-097X
DOI:10.1111/j.1475-097X.2009.00886.x