Receptor assay guided structure-activity studies of helicokinin insect neuropeptides and peptidomimetic analogues

Neuropeptides control numerous physiological processes in insects. The regulation of water balance is a crucial aspect of homeostasis in terrestrial insects and has been shown to be under endocrine control, primarily by corticotrophin releasing factor (CRF)‐related peptides and kinins. For helicokin...

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Bibliographic Details
Published in:Journal of peptide science 2009-11, Vol.15 (11), p.783-789
Main Authors: Scherkenbeck, Jürgen, Antonicek, Horst-Peter, Vogelsang, Kathrin, Zdobinsky, Tino, Brücher, Karin, Rehländer, Denise, Chen, Heru
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
helicokinins
Heliothis virescens
insect neuropeptides
Insect Proteins - chemistry
Insect Proteins - metabolism
Insecta - metabolism
Neuropeptides - chemistry
Neuropeptides - metabolism
peptidomimetic
Protein Binding
Receptors, Neuropeptide - metabolism
structure-activity data
Structure-Activity Relationship
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Summary:Neuropeptides control numerous physiological processes in insects. The regulation of water balance is a crucial aspect of homeostasis in terrestrial insects and has been shown to be under endocrine control, primarily by corticotrophin releasing factor (CRF)‐related peptides and kinins. For helicokinin I, a diuretic neuropeptide from the economically important insect pest Heliothis virescens, detailed structure‐activity relationships have been established based on truncated structures, diverse amino acid scans and peptidomimetic analogues. The activities of selected compounds on functional expressed helicokinin receptors are compared with the results of a Malphigian tubule assay. Implications for further peptidomimetic variations are provided. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
ISSN:1075-2617
1099-1387
DOI:10.1002/psc.1176