The effect of potassium bromate on some haematological parameters of Wistar rats

Potassium bromate used widely in foods has been associated with various complications in humans. However there is paucity of literature on adverse effects on haematological parameters. Thus we decided to carry out an experimental study to determine the effects of potassium bromate on some blood indi...

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Bibliographic Details
Published in:Nigerian journal of physiological sciences 2009-06, Vol.24 (1), p.59-61
Main Authors: Achukwu, P U, Ufelle, S A, Ukaejiofo, E O, Ejezie, F E, Nwachukwu, D N, Nwagha, U I, Nworie, W C, Anyaehie, U S B
Format: Article
Language:English
Subjects:
Animals
Blood Platelets - drug effects
Bromates - toxicity
Food Additives - toxicity
Hematocrit
Hemoglobins - metabolism
Leukocyte Count
Leukocytes - drug effects
Male
Platelet Count
Rats
Rats, Wistar
Risk Assessment
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Summary:Potassium bromate used widely in foods has been associated with various complications in humans. However there is paucity of literature on adverse effects on haematological parameters. Thus we decided to carry out an experimental study to determine the effects of potassium bromate on some blood indices using Wistar rats. Twenty (20) male Wistar rats aged 2-3 months obtained from the department of Veterinary Medicine, University of Nigeria Nsukka were acclimatized for two weeks. They were divided into five groups and fed with graded doses of potassium bromate solution for six weeks. One of the groups served as the control. Pre and post administration blood samples were collected and analyzed the same day using standard methods. The results revealed significant [P
ISSN:0794-859X
0794-859X
DOI:10.4314/njps.v24i1.46383