Sero-negative celiac disease with dermatitis herpetiformes: a case report

INTRODUCTIONWe report a case of sero-negative celiac disease in Pakistan. CASE PRESENTATIONA 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On excl...

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Bibliographic Details
Published in:Cases journal 2009, Vol.2, p.7512-7512
Main Authors: Adhi, Mehreen, Farooq, Asma, Hamid, Syed Ali, Hasan, Rabia, Mamji, Salman, Baloch, Akhtar Ali
Format: Report
Language:English
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Summary:INTRODUCTIONWe report a case of sero-negative celiac disease in Pakistan. CASE PRESENTATIONA 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms. CONCLUSIONNegative serology should not rule out celiac disease; intestinal biopsy should be performed if there is strong clinical suspicion.
ISSN:1757-1626
DOI:10.1186/1757-1626-2-7512