Assessment of preoperative serum prolidase activity in epithelial ovarian cancer

• Published in: European journal of obstetrics & gynecology and reproductive biology 2009-11, Vol.147 (1), p.97-100
• Main Authors: Camuzcuoglu, Hakan, Arioz, Dagistan Tolga, Toy, Harun, Kurt, Sefa, Celik, Hakim, Aksoy, Nurten
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants - metabolism; Biological and medical sciences; CA-125 Antigen - blood; Case-Control Studies; Dipeptidases - blood; Disease Progression; Epithelial ovarian cancer; Extracellular matrix; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Middle Aged; Neoplasm Staging; Neoplasms, Glandular and Epithelial - blood; Neoplasms, Glandular and Epithelial - pathology; Obstetrics and Gynecology; Ovarian Neoplasms - blood; Ovarian Neoplasms - pathology; Oxidants - metabolism; Oxidative stress; Predictive Value of Tests; Preoperative Period; Prolidase activity; Spectrophotometry; Tumors
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/j.ejogrb.2009.07.012

Abstract Objective Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with C-terminal proline and hydroxyproline and plays a major role in collagen turnover. The aim of this study was to evaluate preoperative serum prolidase activity, total oxidant status (TOS), and total antioxidant capacity (TAC) in patients with newly diagnosed epithelial ovarian cancer (EOC). Study design Serum prolidase activity, TOS, and TAC were measured spectrophotometrically in both EOC cases ( n = 28) and controls ( n = 28). Results Preoperative serum prolidase activity and TOS were significantly higher in patients with EOC compared to controls ( p = 0.009 and 0.008, respectively), whereas TAC was significantly lower in cases ( p < 0.001). A significant positive correlation was found between the stage, grade, and CA-125 level of EOC and serum prolidase activity ( rho = 0.466, p = 0.012; rho = 0.501, p = 0.007; and rho = 0.447, p = 0.017, respectively) and TOS ( rho = 0.588, p = 0.001; rho = 0.412, p = 0.029; and rho = 0.568, p = 0.002, respectively). In contrast, there was a negative correlation between TAC and the stage, grade, and CA-125 level of EOC ( rho = −0.555, p = 0.002; rho = −0.566, p = 0.002; and rho = −0.581, p = 0.001, respectively). Conclusion Findings of the present study demonstrate that serum prolidase activity is significantly associated with the stage, tumor grade, and preoperative CA-125 level of EOC.