Psychostimulant treatment for ADHD is modulated by prefrontal cortex manipulation

Abstract The psychostimulant amphetamine (Amph) is widely used treatments for attention-deficit hyperactivity disorder (ADHD). Chronic intermittent exposure to psychostimulants induces behavioral sensitization. The objective of this study was to investigate the role of prefrontal cortex (PFC) in the...

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Bibliographic Details
Published in:Brain research bulletin 2009-12, Vol.80 (6), p.353-358
Main Authors: Tang, A, Wanchoo, S.J, Swann, A.C, Dafny, N
Format: Article
Language:English
Subjects:
Amphetamine
Amphetamine - administration & dosage
Amphetamine - pharmacology
Analysis of Variance
Animals
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - physiopathology
Behavioral sensitization
Catheterization
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - pharmacology
Lesion
Locomotion - drug effects
Male
Motor activity
Neurology
Prefrontal cortex
Prefrontal Cortex - drug effects
Prefrontal Cortex - physiopathology
Random Allocation
Rats
Rats, Sprague-Dawley
Time Factors
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Summary:Abstract The psychostimulant amphetamine (Amph) is widely used treatments for attention-deficit hyperactivity disorder (ADHD). Chronic intermittent exposure to psychostimulants induces behavioral sensitization. The objective of this study was to investigate the role of prefrontal cortex (PFC) in the acute and chronic effect of Amph using the open-field assay. Male Sprague–Dawley rats were assigned randomly to three groups, (1) an intact control group (2) a PFC sham-operated group, and (3) a PFC lesion group. All the three groups showed increases in locomotor activity after acute amphetamine injection ( P < 0.05), and activity levels were especially augmented in PFC lesion group. Following chronic amphetamine, the control group and sham-operated group exhibited behavioral sensitization ( P < 0.05). However, the PFC lesion group failed to exhibit behavioral sensitization and the pattern of locomotion was altered, which indicated that the nature of behavioral sensitization was changed. The results suggest that PFC lesion enhance the acute effects of amphetamine on locomotor activity and is required for development of behavior sensitization.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2009.08.022