MCH receptor peptide agonists and antagonists

Melanin-concentrating hormone (MCH) is an important neuropeptide hormone involved in multiple physiological processes. Peptide derivatives of MCH have been developed as tools to aid research including potent radioligands, receptor selective agonists, and potent antagonists. These tools have been use...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2009-11, Vol.30 (11), p.2008-2013
Main Authors: MacNeil, Douglas J., Bednarek, Maria A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Humans
Hypothalamic Hormones - chemistry
Hypothalamic Hormones - metabolism
MCH
MCHR1
MCHR2
Melanin-concentrating hormone
Melanins - chemistry
Melanins - metabolism
Molecular Sequence Data
Peptide agonist
Peptide antagonist
Peptides - chemistry
Peptides - metabolism
Pituitary Hormones - chemistry
Pituitary Hormones - metabolism
Receptors, Pituitary Hormone - agonists
Receptors, Pituitary Hormone - antagonists & inhibitors
Salmon - metabolism
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Description
Summary:Melanin-concentrating hormone (MCH) is an important neuropeptide hormone involved in multiple physiological processes. Peptide derivatives of MCH have been developed as tools to aid research including potent radioligands, receptor selective agonists, and potent antagonists. These tools have been used to further understand the role of MCH in physiology, primarily in rodents. However, the tools could also help elucidate the role for MCHR1 and MCHR2 in mediating MCH signaling in higher species.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2009.04.009