Frequent CDH3 Demethylation in Advanced Gastric Carcinoma

Background: We recently found that CDH3 was frequently demethylated in advanced colorectal carcinomas. This prompted us to examine the demethylation status of the CDH3 gene in gastric carcinomas. Materials and Methods: The demethylation status of the CDH3 gene was examined in primary tumors derived...

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Bibliographic Details
Published in:Anticancer research 2009-10, Vol.29 (10), p.3945-3947
Main Authors: HIBI, Kenji, KITAMURA, Yo-Hei, SANADA, Yutaka, MIZUKAMI, Hiroki, GOTO, Tetsuhiro, SAKURABA, Kazuma, SAKATA, Makiko, SAITO, Mitsuo, ISHIBASHI, Kazuyoshi, KIGAWA, Gaku, NEMOTO, Hiroshi
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cadherins - genetics
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
DNA Methylation
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Neoplasm Staging
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Background: We recently found that CDH3 was frequently demethylated in advanced colorectal carcinomas. This prompted us to examine the demethylation status of the CDH3 gene in gastric carcinomas. Materials and Methods: The demethylation status of the CDH3 gene was examined in primary tumors derived from 36 patients with gastric carcinoma using a quantitative methylation-specific PCR (qMSP) and was evaluated the correlation between the demethylation status and the clinicopathological findings. Results. Demethylation of the CDH3 gene was detected in 25 out of the 36 (69%) primary gastric carcinomas, suggesting that the aberrant demethylation of CDH3 is a frequent event in gastric carcinomas. Demethylation of CDH3 was significantly associated with increasing TNM stage (p=0.0261). Moreover, a trend was shown toward infiltration beyond the serosa being associated with demethylationof CDH3 (p=0.0733). Conclusion: CDH3 was frequently demethylated in advanced gastric carcinomas.
ISSN:0250-7005
1791-7530