Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer

Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal cancer samples using a quantitative real-time polyme...

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Bibliographic Details
Published in:Anticancer research 2009-10, Vol.29 (10), p.3953-3955
Main Authors: SAKURABA, Kazuma, YASUDA, Takashi, NEMOTO, Hiroshi, SANADA, Yutaka, HIBI, Kenji, SAKATA, Makiko, KITAMURA, Yo-Hei, SHIRAHATA, Atsushi, GOTO, Tetsuhiro, MIZUKAMI, Hiroki, SAITO, Mitsuo, ISHIBASHI, Kazuyoshi, KIGAWA, Gaku
Format: Article
Language:English
Subjects:
Biological and medical sciences
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Down-Regulation
Female
Gastroenterology. Liver. Pancreas. Abdomen
Histone Acetyltransferases - biosynthesis
Histone Acetyltransferases - genetics
Humans
Lysine Acetyltransferase 5
Male
Medical sciences
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal cancer samples using a quantitative real-time polymerase chain reaction. Subsequently, clinicopathological data were correlated with the Tip60 expression score. Results: A down-regulation of the Tip60 gene was observed 5 out of 38 (13%) specimens of primary colorectal cancer. Tip60 down-regulation showed significant correlation with larger tumor size (p=0.0005), poorly differentiated type (p=0.0394), peritoneal dissemination (p=0.0053), distant metastasis (p=0.0394), and higher stage of TNM classification (p=0.0226). Conclusion: These results suggested that Tip60 was more frequently down-regulated in advanced colorectal carcinoma.
ISSN:0250-7005
1791-7530