Loading…
Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer
Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal cancer samples using a quantitative real-time polyme...
Saved in:
| Published in: | Anticancer research 2009-10, Vol.29 (10), p.3953-3955 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 3955 |
| container_issue | 10 |
| container_start_page | 3953 |
| container_title | Anticancer research |
| container_volume | 29 |
| creator | SAKURABA, Kazuma YASUDA, Takashi NEMOTO, Hiroshi SANADA, Yutaka HIBI, Kenji SAKATA, Makiko KITAMURA, Yo-Hei SHIRAHATA, Atsushi GOTO, Tetsuhiro MIZUKAMI, Hiroki SAITO, Mitsuo ISHIBASHI, Kazuyoshi KIGAWA, Gaku |
| description | Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is
linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal
cancer samples using a quantitative real-time polymerase chain reaction. Subsequently, clinicopathological data were correlated
with the Tip60 expression score. Results: A down-regulation of the Tip60 gene was observed 5 out of 38 (13%) specimens of
primary colorectal cancer. Tip60 down-regulation showed significant correlation with larger tumor size (p=0.0005), poorly
differentiated type (p=0.0394), peritoneal dissemination (p=0.0053), distant metastasis (p=0.0394), and higher stage of TNM
classification (p=0.0226). Conclusion: These results suggested that Tip60 was more frequently down-regulated in advanced colorectal
carcinoma. |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_734096900</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734096900</sourcerecordid><originalsourceid>FETCH-LOGICAL-h302t-cd129f7138f1bfbe4878c4a6aad1a63ff20f60a0d0d4b16882a456380754c883</originalsourceid><addsrcrecordid>eNp90MFOwzAMANAKgdgY_ALKBThVcpI2TY6owEAagsNuHCq3TbZA1oyk07S_pxMDbpwsW8-27KNkTAtF0yLncJyMgeWQFgD5KDmL8R1ACCX5aTKiSmZC8XycvN35bZcGvdg47K3viDdkbtcCyFR3mmAkSF59r7veoiPPGD50IMYH0i_1kDq76LBrdvu20jsfdNMPrhxqOpwnJwZd1BeHOEnmD_fz8jGdvUyfyttZuuTA-rRpKVOmoFwaWptaZ7KQTYYCsaUouDEMjACEFtqspkJKhlkuuIQizxop-SS5-R67Dv5zo2NfrWxstHPYab-JVcEzUEIBDPL6X8kolTmwPbw8wE290m21DnaFYVf9_G0AVweAsUFnwnCwjb-OMSiEVPJv49IullsbdBVX6NwwllcYmKooVFzlnH8BkcGCmw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21185020</pqid></control><display><type>article</type><title>Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer</title><source>EZB Electronic Journals Library</source><creator>SAKURABA, Kazuma ; YASUDA, Takashi ; NEMOTO, Hiroshi ; SANADA, Yutaka ; HIBI, Kenji ; SAKATA, Makiko ; KITAMURA, Yo-Hei ; SHIRAHATA, Atsushi ; GOTO, Tetsuhiro ; MIZUKAMI, Hiroki ; SAITO, Mitsuo ; ISHIBASHI, Kazuyoshi ; KIGAWA, Gaku</creator><creatorcontrib>SAKURABA, Kazuma ; YASUDA, Takashi ; NEMOTO, Hiroshi ; SANADA, Yutaka ; HIBI, Kenji ; SAKATA, Makiko ; KITAMURA, Yo-Hei ; SHIRAHATA, Atsushi ; GOTO, Tetsuhiro ; MIZUKAMI, Hiroki ; SAITO, Mitsuo ; ISHIBASHI, Kazuyoshi ; KIGAWA, Gaku</creatorcontrib><description>Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is
linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal
cancer samples using a quantitative real-time polymerase chain reaction. Subsequently, clinicopathological data were correlated
with the Tip60 expression score. Results: A down-regulation of the Tip60 gene was observed 5 out of 38 (13%) specimens of
primary colorectal cancer. Tip60 down-regulation showed significant correlation with larger tumor size (p=0.0005), poorly
differentiated type (p=0.0394), peritoneal dissemination (p=0.0053), distant metastasis (p=0.0394), and higher stage of TNM
classification (p=0.0226). Conclusion: These results suggested that Tip60 was more frequently down-regulated in advanced colorectal
carcinoma.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 19846935</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Biological and medical sciences ; Colorectal Neoplasms - enzymology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Down-Regulation ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Histone Acetyltransferases - biosynthesis ; Histone Acetyltransferases - genetics ; Humans ; Lysine Acetyltransferase 5 ; Male ; Medical sciences ; Middle Aged ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Anticancer research, 2009-10, Vol.29 (10), p.3953-3955</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22076898$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19846935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAKURABA, Kazuma</creatorcontrib><creatorcontrib>YASUDA, Takashi</creatorcontrib><creatorcontrib>NEMOTO, Hiroshi</creatorcontrib><creatorcontrib>SANADA, Yutaka</creatorcontrib><creatorcontrib>HIBI, Kenji</creatorcontrib><creatorcontrib>SAKATA, Makiko</creatorcontrib><creatorcontrib>KITAMURA, Yo-Hei</creatorcontrib><creatorcontrib>SHIRAHATA, Atsushi</creatorcontrib><creatorcontrib>GOTO, Tetsuhiro</creatorcontrib><creatorcontrib>MIZUKAMI, Hiroki</creatorcontrib><creatorcontrib>SAITO, Mitsuo</creatorcontrib><creatorcontrib>ISHIBASHI, Kazuyoshi</creatorcontrib><creatorcontrib>KIGAWA, Gaku</creatorcontrib><title>Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is
linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal
cancer samples using a quantitative real-time polymerase chain reaction. Subsequently, clinicopathological data were correlated
with the Tip60 expression score. Results: A down-regulation of the Tip60 gene was observed 5 out of 38 (13%) specimens of
primary colorectal cancer. Tip60 down-regulation showed significant correlation with larger tumor size (p=0.0005), poorly
differentiated type (p=0.0394), peritoneal dissemination (p=0.0053), distant metastasis (p=0.0394), and higher stage of TNM
classification (p=0.0226). Conclusion: These results suggested that Tip60 was more frequently down-regulated in advanced colorectal
carcinoma.</description><subject>Biological and medical sciences</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Histone Acetyltransferases - biosynthesis</subject><subject>Histone Acetyltransferases - genetics</subject><subject>Humans</subject><subject>Lysine Acetyltransferase 5</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp90MFOwzAMANAKgdgY_ALKBThVcpI2TY6owEAagsNuHCq3TbZA1oyk07S_pxMDbpwsW8-27KNkTAtF0yLncJyMgeWQFgD5KDmL8R1ACCX5aTKiSmZC8XycvN35bZcGvdg47K3viDdkbtcCyFR3mmAkSF59r7veoiPPGD50IMYH0i_1kDq76LBrdvu20jsfdNMPrhxqOpwnJwZd1BeHOEnmD_fz8jGdvUyfyttZuuTA-rRpKVOmoFwaWptaZ7KQTYYCsaUouDEMjACEFtqspkJKhlkuuIQizxop-SS5-R67Dv5zo2NfrWxstHPYab-JVcEzUEIBDPL6X8kolTmwPbw8wE290m21DnaFYVf9_G0AVweAsUFnwnCwjb-OMSiEVPJv49IullsbdBVX6NwwllcYmKooVFzlnH8BkcGCmw</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>SAKURABA, Kazuma</creator><creator>YASUDA, Takashi</creator><creator>NEMOTO, Hiroshi</creator><creator>SANADA, Yutaka</creator><creator>HIBI, Kenji</creator><creator>SAKATA, Makiko</creator><creator>KITAMURA, Yo-Hei</creator><creator>SHIRAHATA, Atsushi</creator><creator>GOTO, Tetsuhiro</creator><creator>MIZUKAMI, Hiroki</creator><creator>SAITO, Mitsuo</creator><creator>ISHIBASHI, Kazuyoshi</creator><creator>KIGAWA, Gaku</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer</title><author>SAKURABA, Kazuma ; YASUDA, Takashi ; NEMOTO, Hiroshi ; SANADA, Yutaka ; HIBI, Kenji ; SAKATA, Makiko ; KITAMURA, Yo-Hei ; SHIRAHATA, Atsushi ; GOTO, Tetsuhiro ; MIZUKAMI, Hiroki ; SAITO, Mitsuo ; ISHIBASHI, Kazuyoshi ; KIGAWA, Gaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h302t-cd129f7138f1bfbe4878c4a6aad1a63ff20f60a0d0d4b16882a456380754c883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Colorectal Neoplasms - enzymology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Histone Acetyltransferases - biosynthesis</topic><topic>Histone Acetyltransferases - genetics</topic><topic>Humans</topic><topic>Lysine Acetyltransferase 5</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAKURABA, Kazuma</creatorcontrib><creatorcontrib>YASUDA, Takashi</creatorcontrib><creatorcontrib>NEMOTO, Hiroshi</creatorcontrib><creatorcontrib>SANADA, Yutaka</creatorcontrib><creatorcontrib>HIBI, Kenji</creatorcontrib><creatorcontrib>SAKATA, Makiko</creatorcontrib><creatorcontrib>KITAMURA, Yo-Hei</creatorcontrib><creatorcontrib>SHIRAHATA, Atsushi</creatorcontrib><creatorcontrib>GOTO, Tetsuhiro</creatorcontrib><creatorcontrib>MIZUKAMI, Hiroki</creatorcontrib><creatorcontrib>SAITO, Mitsuo</creatorcontrib><creatorcontrib>ISHIBASHI, Kazuyoshi</creatorcontrib><creatorcontrib>KIGAWA, Gaku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAKURABA, Kazuma</au><au>YASUDA, Takashi</au><au>NEMOTO, Hiroshi</au><au>SANADA, Yutaka</au><au>HIBI, Kenji</au><au>SAKATA, Makiko</au><au>KITAMURA, Yo-Hei</au><au>SHIRAHATA, Atsushi</au><au>GOTO, Tetsuhiro</au><au>MIZUKAMI, Hiroki</au><au>SAITO, Mitsuo</au><au>ISHIBASHI, Kazuyoshi</au><au>KIGAWA, Gaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>29</volume><issue>10</issue><spage>3953</spage><epage>3955</epage><pages>3953-3955</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is
linked to a growing number of cancer types. Patients and Methods: Tip60 expression levels were in examined in 38 colorectal
cancer samples using a quantitative real-time polymerase chain reaction. Subsequently, clinicopathological data were correlated
with the Tip60 expression score. Results: A down-regulation of the Tip60 gene was observed 5 out of 38 (13%) specimens of
primary colorectal cancer. Tip60 down-regulation showed significant correlation with larger tumor size (p=0.0005), poorly
differentiated type (p=0.0394), peritoneal dissemination (p=0.0053), distant metastasis (p=0.0394), and higher stage of TNM
classification (p=0.0226). Conclusion: These results suggested that Tip60 was more frequently down-regulated in advanced colorectal
carcinoma.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>19846935</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2009-10, Vol.29 (10), p.3953-3955 |
| issn | 0250-7005 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734096900 |
| source | EZB Electronic Journals Library |
| subjects | Biological and medical sciences Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Down-Regulation Female Gastroenterology. Liver. Pancreas. Abdomen Histone Acetyltransferases - biosynthesis Histone Acetyltransferases - genetics Humans Lysine Acetyltransferase 5 Male Medical sciences Middle Aged Reverse Transcriptase Polymerase Chain Reaction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T16%3A46%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Down-regulation%20of%20Tip60%20Gene%20as%20a%20Potential%20Marker%20for%20the%20Malignancy%20of%20Colorectal%20Cancer&rft.jtitle=Anticancer%20research&rft.au=SAKURABA,%20Kazuma&rft.date=2009-10-01&rft.volume=29&rft.issue=10&rft.spage=3953&rft.epage=3955&rft.pages=3953-3955&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E734096900%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-h302t-cd129f7138f1bfbe4878c4a6aad1a63ff20f60a0d0d4b16882a456380754c883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=21185020&rft_id=info:pmid/19846935&rfr_iscdi=true |