Soluble Elastin Decreases in the Progress of Atheroma Formation in Human Aorta

Background: The serum levels of soluble elastin increase in patients with aortic dissection, but its distribution and characteristics are unclear. Methods and Results: The 173 aortic specimens were categorized into 4 groups under microscopy (non-atherosclerotic aorta, n=13; fiber-rich plaque, n=77;...

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Bibliographic Details
Published in:Circulation Journal 2009, Vol.73(11), pp.2154-2162
Main Authors: Akima, Takashi, Nakanishi, Kuniaki, Suzuki, Kimihiro, Katayama, Masahiko, Ohsuzu, Fumitaka, Kawai, Toshiaki
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aorta - metabolism
Aorta - pathology
Atherosclerosis
Atherosclerosis - etiology
Atherosclerosis - genetics
Atherosclerosis - metabolism
Atherosclerosis - pathology
Base Sequence
Blotting, Western
DNA Primers - genetics
Elastin
Elastin - genetics
Elastin - metabolism
Female
Humans
In Situ Hybridization
Male
Matrix Metalloproteinase 9 - metabolism
Middle Aged
Pathology
Plaque
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Solubility
Tissue Distribution
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Summary:Background: The serum levels of soluble elastin increase in patients with aortic dissection, but its distribution and characteristics are unclear. Methods and Results: The 173 aortic specimens were categorized into 4 groups under microscopy (non-atherosclerotic aorta, n=13; fiber-rich plaque, n=77; lipid-rich plaque, n=66; ruptured plaque, n=17). Soluble elastin was abundant within the intima of both the non-atherosclerotic aorta and fiber-rich plaque, rather than in the media, and was decreased within the intima of lipid-rich and ruptured plaques. Soluble elastin levels decreased with progress of atherosclerosis (6.0 ±0.3 μg/mg protein in non-atherosclerotic aorta; 5.8 ±0.2 μg/mg protein in fiber-rich plaque; 4.9 ±0.2 μg/mg protein in lipid-rich plaque; 2.8 ±0.4 μg/mg protein in ruptured plaque, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-09-0104