Grafting of molecularly imprinted polymers on iniferter-modified carbon nanotube

Molecularly imprinted polymers (MIPs) were grafted on iniferter-modified carbon nanotube (CNT). Tween 20 was first immobilized on CNT by hydrophobic interactions. The hydroxyl-functionalized CNT was modified by silanisation with 3-chloropropyl trimethoxysilane. The iniferter groups were then introdu...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2009-11, Vol.25 (3), p.587-591
Main Authors: Lee, H.-Y., S. Kim, B.
Format: Article
Language:English
Subjects:
Binding Sites
Biological and medical sciences
Biosensing Techniques
Biotechnology
Caffeine - chemistry
Carbon nanotube
Fundamental and applied biological sciences. Psychology
Grafting
Iniferter
Kinetics
Microscopy, Electron, Scanning
Molecular Imprinting - methods
Molecular Structure
Molecularly imprinted polymers
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - ultrastructure
Polymers - chemical synthesis
Polymers - chemistry
Theobromine - chemistry
Theophylline - chemistry
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Summary:Molecularly imprinted polymers (MIPs) were grafted on iniferter-modified carbon nanotube (CNT). Tween 20 was first immobilized on CNT by hydrophobic interactions. The hydroxyl-functionalized CNT was modified by silanisation with 3-chloropropyl trimethoxysilane. The iniferter groups were then introduced by reacting the CNT-bound chloropropyl groups with sodium N, N-diethyldithiocarbamate. UV light-initiated copolymerization of ethylene glycol dimethacrylate (crosslinking agent) and methacrylic acid (functional monomer) resulted in grafting of MIP on CNT for theophylline as a model template. MIPs grafted on CNT were characterized with elemental analysis, scanning electron microscopy, and thermogravimetric analysis. The theophylline-imprinted polymer on CNT showed higher binding capacity for theophylline than non-imprinted polymer on CNT and selectivity for theophylline over caffeine and theobromine (similar structure molecules). The data of theophylline and caffeine binding into the theophylline-imprinted polymer correlated well with the Scatchard plot. These MIPs on CNT can potentially be applied to probe materials in biosensor system based on CNT field effect transistor.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2009.03.040