Use of the frontal assessment battery in evaluating executive dysfunction in patients with Huntington’s disease

The frontal assessment battery (FAB) is a bedside cognitive scale designed to measure executive functions. Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, behavioral, and cognitive dysfunction. The aim of this study was to check the validity of the FAB for the evalu...

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Bibliographic Details
Published in:Journal of neurology 2009-11, Vol.256 (11), p.1809-1815
Main Authors: Rodrigues, Guilherme Riccioppo, Souza, Carolina Pinto, Cetlin, Roberto Satler, de Oliveira, Daniel Sabino, Pena-Pereira, Marcio, Ujikawa, Liliana Tiemi, Marques, Wilson, Tumas, Vitor
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Alzheimer's disease
Analysis of Variance
Behavior
Biological and medical sciences
Brain damage
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Cognitive ability
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Educational Status
Executive function
Executive Function - physiology
Female
Humans
Huntington Disease - complications
Huntingtons disease
Longitudinal Studies
Male
Medical sciences
Medicine
Medicine & Public Health
Mental Status Schedule
Middle Aged
Neurology
Neuropsychological Tests
Neuroradiology
Neurosciences
Original Communication
Regression Analysis
Reproducibility of Results
ROC Curve
Validity
Young Adult
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Summary:The frontal assessment battery (FAB) is a bedside cognitive scale designed to measure executive functions. Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, behavioral, and cognitive dysfunction. The aim of this study was to check the validity of the FAB for the evaluation of cognitive impairment in patients with HD. Forty-one patients diagnosed with HD and 53 healthy controls matched by education, sex and age were evaluated with a validated Brazilian version of the UHDRS, the VFT, the SDMT, the SIT, the MMSE, and the FAB. The diagnosis of HD was made by DNA analysis. FAB scores were lower in patients than in the controls ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-009-5197-0