Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: Which biological markers of the liver function affect the enhancement?

Purpose: To clarify the factors that predict enhancement of the liver parenchyma in hepatocyte‐phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MR imaging. Materials and Methods: Gd‐EOB‐DTPA–enhanced hepatocyte‐phase MR images of 198 patients with chronic li...

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Published in:Journal of magnetic resonance imaging 2009-11, Vol.30 (5), p.1042-1046
Main Authors: Motosugi, Utaroh, Ichikawa, Tomoaki, Sou, Hironobu, Sano, Katsuhiro, Tominaga, Licht, Kitamura, Takatoshi, Araki, Tsutomu
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - metabolism
Body Weight
Contrast Media - pharmacology
Female
Gadolinium DTPA - pharmacology
gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)
Hepatocytes - metabolism
Hepatocytes - pathology
Humans
liver
Liver - pathology
liver function
Magnetic Resonance Imaging - methods
Male
Middle Aged
MR imaging
Regression Analysis
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Summary:Purpose: To clarify the factors that predict enhancement of the liver parenchyma in hepatocyte‐phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MR imaging. Materials and Methods: Gd‐EOB‐DTPA–enhanced hepatocyte‐phase MR images of 198 patients with chronic liver diseases (Child‐Pugh class A in 112 patients, class B in 74 patients, and class C in 12 patients) were retrospectively analyzed. The hepatocyte‐phase images were obtained using fat‐suppressed T1‐weighted gradient‐echo images with a 3D acquisition sequence 10 min and 20 min after IV administration of Gd‐EOB‐DTPA (0.025 mmol/kg body weight). The quantitative liver–spleen contrast ratio (Q‐LSC) was calculated using the signal intensities of the liver and spleen. Serum albumin levels, total bilirubin levels, prothrombin activity, and the results of indocyanine green clearance tests (ICGs) were recorded and correlated with the Q‐LSC. Logistic regression analysis was performed to analyze which factors predict sufficient liver enhancement using a Q‐LSC of 1.5 as a cutoff value. Results: Only ICGs and Child‐Pugh classifications showed a statistically significant correlation with the Q‐LSC. Logistic regression analysis showed that ICGs were the only factors that accurately predicted liver enhancement on hepatocyte‐phase images. Conclusion: ICGs were found to be predictors of sufficient liver enhancement on hepatocyte‐phase images. J. Magn. Reson. Imaging 2009;30:1042–1046. © 2009 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.21956