Measurement of R1 dynamics using sliding window-DESPOT

Purpose: To measure longitudinal relaxation rate (R1) changes during contrast agent studies using a driven equilibrium single pulse observation of T1 (DESPOT) method with a sliding window (sw) acquisition. Materials and Methods: A sw‐DESPOT technique was implemented that uses several three‐dimension...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2009-11, Vol.30 (5), p.1163-1170
Main Authors: Schulz, Jessica, Korn, Matthias, Woenne, Eva C., Umathum, Reiner, Briel, Andreas, Hengerer, Arne, Semmler, Wolfhard, Bock, Michael
Format: Article
Language:English
Subjects:
Algorithms
Animals
Contrast Media - pharmacology
driven equilibrium single pulse observation of T1 (DESPOT)
Humans
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Mice
Models, Statistical
MR contrast agent
Phantoms, Imaging
relaxometry
Software
Time Factors
variable flip angle
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Summary:Purpose: To measure longitudinal relaxation rate (R1) changes during contrast agent studies using a driven equilibrium single pulse observation of T1 (DESPOT) method with a sliding window (sw) acquisition. Materials and Methods: A sw‐DESPOT technique was implemented that uses several three‐dimensional (3D) image data sets to calculate R1 with a temporal resolution of only a single data set. Different sources of systematic errors were studied in simulations, and the technique was tested in a tumor‐bearing mouse using an intravascular contrast agent. Results: Consistent concentration distributions of the CA were calculated with a temporal resolution of 10 s. Conclusion: Sw‐DESPOT offers a precise and fast method to monitor the CA dynamics in 3D volumes. J. Magn. Reson. Imaging 2009;30:1163–1170. © 2009 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.21946