Erythrocyte fatty acid profiles can predict acute non-fatal myocardial infarction

The risk of CHD has been linked to n-3 and trans-fatty acids. The purpose of the present study was to evaluate the hypothesis that lower n-3 fatty acids and higher trans-fatty acids in erythrocytes are associated with an increased risk of acute non-fatal myocardial infarction (MI), and that fatty ac...

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Bibliographic Details
Published in:British journal of nutrition 2009-11, Vol.102 (9), p.1355-1361
Main Authors: Park, Yongsoon, Lim, Jeehyun, Lee, Jaeung, Kim, Soon-gil
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
Cardiovascular disease
Case-Control Studies
Discrimination
docosahexaenoic acid
eicosapentaenoic acid
Erythrocytes
Erythrocytes - metabolism
fatty acid composition
Fatty acids
Fatty Acids, Omega-3 - blood
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Heart attacks
Human and Clinical Nutrition
human diseases
human nutrition
Humans
Lipidome
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - blood
n-3 Fatty acids
omega-3 fatty acids
patients
prediction
Prognosis
Risk Factors
Risk reduction
Trans Fatty Acids - blood
Trans-fatty acids
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The risk of CHD has been linked to n-3 and trans-fatty acids. The purpose of the present study was to evaluate the hypothesis that lower n-3 fatty acids and higher trans-fatty acids in erythrocytes are associated with an increased risk of acute non-fatal myocardial infarction (MI), and that fatty acid profiles can discriminate MI cases from controls. Fifty cases with acute non-fatal MI and fifty age- and sex-matched controls without MI were recruited. The Omega-3 Index (the sum of EPA and DHA in erythrocytes) was significantly lower in cases than controls (9·57 (sem 0·28) v. 11·81 (sem 0·35) %; P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114509990298