Synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazides

Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2009-01, Vol.7 (22), p.4641-4646
Main Authors: Chen, Zhiyuan, Su, Mingchao, Yu, Xingxin, Wu, Jie
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Amides - chemistry
Bromine - chemistry
Catalysis
Hydrazines - chemistry
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Palladium - chemistry
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Summary:Diversity-oriented synthesis of functionalized H-pyrazolo[5,1-a]isoquinolines via sequential reactions of N'-(2-alkynylbenzylidene)hydrazide is described. Bromine-mediated electrophilic cyclization, Ag-catalyzed alkyne nucleophilic addition, and palladium-catalyzed cross-coupling reaction were involved in the transformation.
ISSN:1477-0520
1477-0539
DOI:10.1039/b914265g