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Cell sex determines anoikis resistance in vascular smooth muscle cells
Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison wi...
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| Published in: | FEBS letters 2009-11, Vol.583 (21), p.3448-3454 |
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| Main Authors: | , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c507X-280bf91eb61255409237a9813446da02546acc7ca231d187ef9d557724b1e29f3 |
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| cites | cdi_FETCH-LOGICAL-c507X-280bf91eb61255409237a9813446da02546acc7ca231d187ef9d557724b1e29f3 |
| container_end_page | 3454 |
| container_issue | 21 |
| container_start_page | 3448 |
| container_title | FEBS letters |
| container_volume | 583 |
| creator | Straface, Elisabetta Vona, Rosa Gambardella, Lucrezia Ascione, Barbara Marino, Maria Bulzomi, Paola Canu, Silvia Coinu, Rita Rosano, Giuseppe Malorni, Walter Franconi, Flavia |
| description | Sexual dimorphism, detectable in vascular smooth muscle cells freshly isolated from aorta of male and female rats, is associated with a different susceptibility to radiation-induced apoptosis. In this work we investigated the mechanism underlying this difference and discovered that, in comparison with cells from male rats, cells from female rats show adhesion-associated resistance to apoptosis, the so called anoikis resistance. This is apparently due to a more adhering phenotype, characterized by a well organized actin microfilament cytoskeleton and to an increased phosphorylated focal adhesion kinase, and, more importantly, to a higher propensity to undergo survival by autophagy. |
| doi_str_mv | 10.1016/j.febslet.2009.09.052 |
| format | article |
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| source | Wiley; ScienceDirect Journals |
| subjects | 4-HNE 4-hydroxynonenal Actins - metabolism androgen receptors Animals Anoikis Apoptosis Autophagy Cell Adhesion Cytoskeleton - metabolism ERs estradiol estrogen receptors FAK Female female-derived vascular smooth muscle cells focal adhesion kinase FVSMC Gender Male male-derived vascular smooth muscle cells Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism MVSMC Oxidation-Reduction p-FAK phosphorylated focal adhesion kinase Phosphorylation Rats Reactive oxygen species ROS scanning electron microscopy SEM Senescence Sex Characteristics ultraviolet B radiation UVB Vascular smooth muscle cells VSMC |
| title | Cell sex determines anoikis resistance in vascular smooth muscle cells |
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