Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients

Abstract Natural killer (NK) activity of immune cells plays a central role in host defense against cancer and virus-infected cells. Natural cytotoxic activity of peripheral-blood mononuclear cells was assessed by a Calcein-AM release assay in 89 subjects. In the present study, we here demonstrated t...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2009-11, Vol.63 (9), p.703-706
Main Authors: Dewan, Md. Zahidunnabi, Takada, Masahiro, Terunuma, Hiroshi, Deng, Xuewen, Ahmed, Sunjida, Yamamoto, Naoki, Toi, Masakazu
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast cancer
Breast Neoplasms - immunology
Female
Gynecology. Andrology. Obstetrics
Humans
Internal Medicine
K562 Cells
Killer Cells, Natural - immunology
Leukocytes, Mononuclear - immunology
Mammary gland diseases
Medical Education
Medical sciences
Middle Aged
NK activity
NK cell
PBMCs
Pharmacology. Drug treatments
Tumors
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Summary:Abstract Natural killer (NK) activity of immune cells plays a central role in host defense against cancer and virus-infected cells. Natural cytotoxic activity of peripheral-blood mononuclear cells was assessed by a Calcein-AM release assay in 89 subjects. In the present study, we here demonstrated that NK activities of peripheral-blood mononuclear cells (PBMCs) from breast cancer patients were significantly lower as compared with that of healthy individuals. There were significant differences in the NK activities of PBMCs from HER2-negative breast cancer patients as compared with HER2-positive patients. Our results suggest that NK activity of PBMCs is lower in breast cancer indicating a role for immunological natural host defense mechanisms against cancer.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2009.02.003