Quiet Gene Circuit More Fragile Than Its Noisy Peer

Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Çağatay et al. (2009) use a synthetic biology approach to show that fluctuations—or noise—in protein levels may play a key role in determining which network design is selected during evolution.

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Bibliographic Details
Published in:Cell 2009-10, Vol.139 (3), p.460-461
Main Authors: Bollenbach, Tobias, Kishony, Roy
Format: Article
Language:English
Subjects:
Bacillus subtilis - genetics
Bacillus subtilis - physiology
Biological Evolution
Gene Regulatory Networks
Models, Biological
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Description
Summary:Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Çağatay et al. (2009) use a synthetic biology approach to show that fluctuations—or noise—in protein levels may play a key role in determining which network design is selected during evolution.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.10.005