Pathogenic role of anti-endothelial cell antibodies in autoimmune rheumatic diseases

Anti-endothelial cells antibodies have been detected in numerous autoimmune and inflammatory diseases, including systemic lupus erythematous, rheumatoid arthritis, vasculitis and sarcoidosis. Anti-endothelial cells antibodies bind to endothelial cell antigens and induce endothelial damage. Their eff...

Full description

Saved in:
Bibliographic Details
Published in:Lupus 2009-11, Vol.18 (13), p.1233-1238
Main Authors: Domiciano, DS, Carvalho, JF, Shoenfeld, Y.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoantibodies - immunology
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Cardiovascular disease
Chemokines
Cytokines
Cytotoxicity
Endothelial Cells - cytology
Endothelial Cells - immunology
Endothelial Cells - pathology
Endothelium, Vascular - cytology
Endothelium, Vascular - immunology
Endothelium, Vascular - pathology
Heparan sulfate
Humans
Lupus
Medicine
Neutrophils
Pathogenesis
Rheumatic diseases
Rheumatic Diseases - immunology
Rheumatic Diseases - pathology
Rheumatoid arthritis
Sarcoidosis
Scleroderma
Thrombosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anti-endothelial cells antibodies have been detected in numerous autoimmune and inflammatory diseases, including systemic lupus erythematous, rheumatoid arthritis, vasculitis and sarcoidosis. Anti-endothelial cells antibodies bind to endothelial cell antigens and induce endothelial damage. Their effects on the endothelial cell have been considered responsible, at least in part, by the vascular injury which occurs in these pathological conditions.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203309346654