Male specific association between the 5-HTR6 gene 267C/T SNP and suicide in the Portuguese population

Serotonergic system dysfunction has been implicated in the etiology of suicide. A large number of genetic studies have focused on the potential involvement of genes coding for components of serotonergic system in suicidal behavior. However, other genes belonging to this system remain to be investiga...

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Bibliographic Details
Published in:Neuroscience letters 2009-12, Vol.466 (3), p.128-130
Main Authors: Azenha, Diana, Alves, Mariana, Matos, Rita, Santa, Jerónimo Fonte, Silva, Beatriz, Cordeiro, Cristina, Vieira, Duarte Nuno, Ambrósio, Alda M.
Format: Article
Language:English
Subjects:
267C/T SNP
5-HTR6 gene
Adolescent
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Predisposition to Disease
Genetics
Genotype
Humans
Male
Male suicide victims
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide
Portugal
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Serotonin - genetics
Sex Factors
Suicide
Vertebrates: nervous system and sense organs
Young Adult
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Summary:Serotonergic system dysfunction has been implicated in the etiology of suicide. A large number of genetic studies have focused on the potential involvement of genes coding for components of serotonergic system in suicidal behavior. However, other genes belonging to this system remain to be investigated or have been poorly studied, as is the case of the 5-HT6 receptor (5-HTR6) gene. In this study, we investigated the potential association between the 5-HTR6 gene 267C/T SNP and suicide in a Portuguese population. Blood samples were collected from 179 suicide victims and 189 controls. Genotypes for the 5-HTR6 gene 267C/T SNP were obtained with the restriction enzyme Rsa I. A tendency was found for genotype association between this polymorphism and suicide, but the differences were not statistically significant ( χ 2 = 5.374, df = 2, p = 0.068). However, a gender-specific association was detected when comparing the genotype distribution between male suicide victims and male controls ( χ 2 = 6.988, df = 2, p = 0.030), suggesting that this SNP might have a role in the etiology of suicide in male subjects in the Portuguese population.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2009.09.040