Nocturnal hypoxia and sleep disturbances in cystic fibrosis

Disrupted sleep and nocturnal hypoxia are common in cystic fibrosis (CF). However, the predictors of nocturnal hypoxia in CF are still controversial. In order to identify the risk factors for nocturnal desaturation and sleep disturbances, we carried out a clinical and polysomnographic investigation...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric pulmonology 2009-11, Vol.44 (11), p.1143-1150
Main Authors: de Castro-Silva, Claudia, de Bruin, Veralice Meireles Sales, Cavalcante, Antonio George Matos, Bittencourt, Lia Rita Azeredo, de Bruin, Pedro Felipe Carvalhedo
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Body Mass Index
Case-Control Studies
Child
cystic fibrosis
Cystic Fibrosis - complications
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Errors of metabolism
Female
FEV1
Forced Expiratory Volume
General aspects
Humans
hypoxia
Hypoxia - diagnosis
Hypoxia - etiology
Male
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
Nervous system (semeiology, syndromes)
Neurology
Oximetry
Pneumology
Polysomnography
Respiratory system : syndromes and miscellaneous diseases
Risk Factors
ROC Curve
SaO2
sleep apnea
Sleep Apnea Syndromes - diagnosis
Sleep Apnea Syndromes - etiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Disrupted sleep and nocturnal hypoxia are common in cystic fibrosis (CF). However, the predictors of nocturnal hypoxia in CF are still controversial. In order to identify the risk factors for nocturnal desaturation and sleep disturbances, we carried out a clinical and polysomnographic investigation of CF patients. We studied 30 clinically stable CF cases with clinical lung disease (mean age = 12.8; mean FEV1 = 65.2), 10 CF cases without significant lung disease (mean age = 13.3; mean FEV1 = 99.8), and 20 controls (mean age = 15.5). Patients were evaluated by spirometry, 6‐min walk test, the Shwachman–Kulczycki (S–K) score, and full overnight polysomnography. Cases with clinical lung disease had lower body mass index, forced vital capacity, and S–K scores. During sleep, five CF cases with clinical lung disease (15%) had SaO2
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.21122