LTA 252GG and GA Genotypes are Associated with Diffuse-Type Noncardia Gastric Cancer Risk in the Japanese Population

Background:  There are limited numbers of reports on the association of lymphotoxin‐alpha (LTA) genotypes with gastric cancer. Methods:  A nested case–control study was carried out in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean, 2.3 years) and blood cell...

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Bibliographic Details
Published in:Helicobacter (Cambridge, Mass.) Mass.), 2009-12, Vol.14 (6), p.571-579
Main Authors: Suzuki, Gen, Cullings, Harry, Fujiwara, Saeko, Matsuura, Shinsuke, Kishi, Takeshi, Ohishi, Waka, Akahoshi, Masazumi, Hayashi, Tomonori, Tahara, Eiichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial - blood
Antigens, Bacterial - immunology
Bacterial Proteins - immunology
Case-Control Studies
Epidemiology
Female
gastric cancer
Genotype
Helicobacter Infections - epidemiology
Helicobacter Infections - genetics
Helicobacter Infections - immunology
Helicobacter Infections - pathology
Helicobacter pylori - immunology
Helicobacter pylori - physiology
Humans
Japan - epidemiology
Longitudinal Studies
LTA
Lymphotoxin-alpha - genetics
Male
Middle Aged
radiation
smoking
Stomach Neoplasms - epidemiology
Stomach Neoplasms - genetics
Stomach Neoplasms - immunology
Stomach Neoplasms - pathology
Young Adult
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Summary:Background:  There are limited numbers of reports on the association of lymphotoxin‐alpha (LTA) genotypes with gastric cancer. Methods:  A nested case–control study was carried out in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean, 2.3 years) and blood cells. Enrolled were 287 cases with noncardia gastric cancer of diffuse and intestinal types and three controls per case selected from cohort members matched on age, gender, city, and time and type of serum storage and counter‐matched on radiation dose. Results:  LTA 252GG and GA genotypes were associated with the prevalence of Helicobacter pylori IgG seropositivity and higher antibody titer against H. pylori cytotoxin‐associated gene A (CagA) protein in controls and they were an independent risk factor for noncardia gastric cancer of diffuse type (RR = 2.8 (95% CI: 1.3–6.3), p = .01, and RR = 2.7 (95% CI: 1.5–4.8), p 
ISSN:1083-4389
1523-5378
DOI:10.1111/j.1523-5378.2009.00694.x