Treatment of Recurrent Priapism in Sickle Cell Anemia With Finasteride: A New Approach

• Published in: Urology (Ridgewood, N.J.) N.J.), 2009-11, Vol.74 (5), p.1054-1057
• Main Authors: Rachid-Filho, Daibes, Cavalcanti, Andre G, Favorito, Luciano A, Costa, Waldemar S, Sampaio, Francisco J.B
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - complications; Biological and medical sciences; Enzyme Inhibitors - therapeutic use; Finasteride - therapeutic use; Gynecology. Andrology. Obstetrics; Humans; Male; Male genital diseases; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Non tumoral diseases; Priapism - drug therapy; Priapism - etiology; Recurrence; Urology; Young Adult
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/j.urology.2009.04.071

Objectives To determine whether the use of finasteride controls recurrent priapism in patients with sickle cell anemia. Methods Thirty-five patients with recurrent priapism because of sickle cell disease received finasteride during 120 days. The initial dose was decreased every 40 days, from 5 mg/d to 3 mg and then to 1 mg of finasteride until the end of 120 days. Five groups (G) were created based on priapism episodes in a month: G0, no episode; G1, 1-15 episodes; G2, 16-30; G3, 31-45; and G4, >45 episodes. Results Records on day 0: G0, no patient; G1, 7 (20%); G2, 21 (60%); G3, 4 (12%); and G4: 3 (8%). After 40 days of using 5 mg/d finasteride we found the following results: G0, 5 patients (14%); G1, 19 (55%); G2, 8 (23%); G3, 3 (8%); and G4, none. At the end of the 40-day period, using 3 mg/d finasteride, the findings were as follows: G0, 19 patients (55%); G1, 14 (39%); G2, 2 (6%); G3, none; and G4, none. The findings after 120 days with 1 mg/d finasteride for the last 40 days were as follows: 16 patients (46%) and G1, 16 (46%). In 1 patient, the dose was increased to 3 mg and in 2 patients, to 5 mg, so as to achieve remission. Conclusions To our knowledge, this is the first study demonstrating that the use of finasteride could decrease and control the number of priapism recurrences in patients with sickle cell anemia, with fewer side effects than other drugs currently used.